ScienceDaily (July 19, 2012) Not all adult stem cells are created equal. Some are busy regenerating worn out or damaged tissues, while their quieter brethren serve as a strategic back-up crew that only steps in when demand shoots up. Now, researchers at the Stowers Institute for Medical Research have identified an important molecular cue that keeps quiescent mouse hematopoietic (or blood-forming) stem cells from proliferating when their services are not needed. Publishing in the July 20, 2012 issue of Cell, the team led by Stowers Investigator Linheng Li, Ph.D., report that Flamingo and Frizzled 8, a tag team best known for its role in establishing cell polarity, are crucial for maintaining a quiescent reserve pool of hematopoietic stem cells in mouse bone marrow. Their finding adds new insight into the mechanism that controls the delicate balance between long-term maintenance of stem cells and the requirements of ongoing tissue maintenance and regeneration. "Hematopoietic stem cells daily produce billions of blood cells via a strict hierarchy of lineage-specific progenitors," says Li. "Identifying the molecular signals that allow hematopoietic stem cell populations to sustain this level of output over a lifetime is fundamental to understanding the development of different cell types, the nature … Continue reading →

DUBLIN--(BUSINESS WIRE)-- Research and Markets (http://www.researchandmarkets.com/research/mjblwp/disease_and_therap) has announced the addition of the "Disease and Therapy Review: Epilepsy" report to their offering. The Epilepsy Disease and Therapy Review provides an overview of the disease and related conditions, with incidence and prevalence numbers and percentages for major countries worldwide, information on diagnosis, and an overview of treatment. Dosing and treatment cost information is provided for various treatment types. General information on the epilepsy market, as well as sales of leading drugs and therapies are provided. Disease and Therapy Reviews were developed to provide a basic understanding of the key facts about a disease and market in a quick, easy-to-read format. These reports are prepared by the senior market research team of Timely Data Resources. Each Disease and TherapyReview provides a conciseanalysis of the most important informationabout a particular disease, its treatment, and the market opportunities. Reports begin with an overview of the condition, and also contain tables that summarize the available worldwide incidence and prevalence data for the condition, a review of current diagnosis strategiesand treatment options, general information about the market size, and information about important market trends. Thedata contained in these reportscomes fromkey industry secondary data sources,such asthe Timely Data … Continue reading →

Franklin Hospital is participating in the American Heart Association/American Stroke Associations Get With The Guidelines Stroke program. Emergency room director Shirley Spangler said the programs goal is to improve the overall quality of care for stroke patients by improving acute stroke treatment and preventing future strokes and cardiovascular events. Lee H. Schwamm, M.D. and chair of the Get With The Guidelines National Steering Committee and director of the TeleStroke and Acute Stroke Services at Massachusetts General Hospital in Boston commends the hospital for its commitment to implementing standards of care and protocols for treating stroke patients. Get With The Guidelines Stroke was developed to help hospitals employ proven science-based treatment guidelines, including those developed by the American Stroke Association, American Heart Association and Brain Attack Coalition, he said. These guidelines address acute stroke management, primary prevention of cardiovascular diseases, secondary prevention of strokes and the establishment of primary stroke centers. Spangler said as a program participant, Franklin Hospital is encouraged to develop a comprehensive system for providing rapid diagnosis and treatment of stroke when patients are admitted to the emergency department. This includes being equipped to provide brain-imaging scans, making neurologists available to conduct patient evaluations and using clot-busting medications … Continue reading →