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Mechanisms that allow embryonic stem cells to become any cell in the human body identified

Posted: Published on July 18th, 2012

ScienceDaily (July 18, 2012) New research at the Hebrew University of Jerusalem sheds light on pluripotency -- the ability of embryonic stem cells to renew themselves indefinitely and to differentiate into all types of mature cells. Solving this problem, which is a major challenge in modern biology, could expedite the use of embryonic stem cells in cell therapy and regenerative medicine. If scientists can replicate the mechanisms that make pluripotency possible, they could create cells in the laboratory which could be implanted in humans to cure diseases characterized by cell death, such as Alzheimer's, Parkinson's, diabetes and other degenerative diseases. To shed light on these processes, researchers in the lab of Dr. Eran Meshorer, in the Department of Genetics at the Hebrew University's Alexander Silberman Institute of Life Sciences, are combining molecular, microscopic and genomic approaches. Meshorer's team is focusing on epigenetic pathways -- which cause biological changes without a corresponding change in the DNA sequence -- that are specific to embryonic stem cells. The molecular basis for epigenetic mechanisms is chromatin, which is comprised of a cell's DNA and structural and regulatory proteins. In groundbreaking research performed by Shai Melcer, a PhD student in the Meshorer lab, the mechanisms … Continue reading →

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Nanomedicine: Bringing brighter light into living bodies

Posted: Published on July 18th, 2012

ScienceDaily (July 18, 2012) Fluorescent nanoparticles loaded with organic light-emitting dyes are expected to transform live-animal imaging technologies. Compared to inorganic quantum dots, these optically stable materials are non-toxic and can easily be modified with functional groups, making them ideal when targeting specific tissues in the body. Unfortunately, traditional dyes have been known to aggregate and lose their emission intensity when incorporated in nanoparticles at high concentration. To overcome this problem, a team of researchers led by Bin Liu and Ben Zhong Tang at the A*STAR Institute of Materials Research and Engineering have now designed a family of dyes with enhanced fluorescence upon aggregation. At the heart of the traditional dyes is a planar chromophore called triphenylamine-modified dicyanomethylene, which emits red light in dilute solutions but fluoresces weakly when aggregated. "The close vicinity of the chromophores induces fluorescence quenching due to non-radiative pathways," says Liu. Liu, Tang and their team reversed this phenomenon by attaching propeller-shaped tetraphenylethene pendants to each extremity of the chromophore. Contrary to planar compounds, the shape of the propellers prevents strong stacking interactions between chromophores, blocking the aggregation-caused quenching process. In addition, the physical confinement prevents these propellers from rotating freely, enabling light emission. The team … Continue reading →

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Fake drugs for erectile dysfunction may bring, not a 'Grade 4' score, but death – experts

Posted: Published on July 18th, 2012

17-Jul-12, 5:45 PM | Pots de Leon, InterAksyon.com OTHER SPECIAL FEATURES STORIES InterAksyon.com The online news portal of TV5 MANILA, Philippines The maker of one of the largest-selling drugs for erectile dysfunction on Tuesday sounded the alarm against counterfeits that promise quick results but could cause serious reactions, or possibly even death. On a scale of 1 to 4, with 4 being the highest, the most potent forms of Sildenafil could reward users with a Grade 4 in terms of "Erection Hardness Score" (EHS), a unit of measure for erection hardness and quality. But the use of counterfeits could lead to adverse reactions, experts are warning. Pfizer Philippines made the warning after authorities seized last week several boxes of suspected counterfeit MagnaRX drugs being sold in drugstores along Binondo and Ongpin in Manila. Pfizer is the manufacturer of Viagra, one of the most popular brands for erectile dysfunction pills. MagnaRX appears to be sourced from China and purports to treat erectile dysfunction. According to Pfizers senior medical manager Dr. James Wee, patients who take counterfeit Sildenafil may experience unexpected side effects, allergic reactions, worsening of their medical condition, or even death. The manufacturing sites of these counterfeit medicines are not … Continue reading →

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Hard truth: Fake erectile dysfunction drugs can kill, experts warn

Posted: Published on July 18th, 2012

17-Jul-12, 5:45 PM | Pots de Leon, InterAksyon.com OTHER SPECIAL FEATURES STORIES InterAksyon.com The online news portal of TV5 MANILA, Philippines The maker of one of the largest-selling drugs for erectile dysfunction on Tuesday sounded the alarm against counterfeits that promise quick results but could cause serious reactions, or possibly even death. On a scale of 1 to 4, with 4 being the highest, the most potent forms of Sildenafil could reward users with a Grade 4 in terms of "Erection Hardness Score" (EHS), a unit of measure for erection hardness and quality. But the use of counterfeits could lead to adverse reactions, experts are warning. Pfizer Philippines made the warning after authorities seized last week several boxes of suspected counterfeit MagnaRX drugs being sold in drugstores along Binondo and Ongpin in Manila. Pfizer is the manufacturer of Viagra, one of the most popular brands for erectile dysfunction pills. MagnaRX appears to be sourced from China and purports to treat erectile dysfunction. According to Pfizers senior medical manager Dr. James Wee, patients who take counterfeit Sildenafil may experience unexpected side effects, allergic reactions, worsening of their medical condition, or even death. The manufacturing sites of these counterfeit medicines are not … Continue reading →

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Man gets 1 year for selling fake erectile dysfunction pills

Posted: Published on July 18th, 2012

A Canoga Park man charged with selling fake erectile dysfunction pills on Craigslist was sentenced to a year and a day in federal prison, authorities said Tuesday. The case against Barry Ronnel Johnson, 38, began in March 2011 after customs officers at Los Angeles International Airport intercepted a package with more than 1,700 counterfeit pills. The shipment was bound for Johnson's home, according to the U.S. Department of Homeland Security. Johnson was charged with selling 30 blue labeled "Filagra" to a Homeland Security undercover agent posing as a buyer on Craigslist. Johnson pleaded guilty in March to one count of trafficking and importing counterfeit goods. He was also ordered to serve a year of home detention after his release from prison. "This sentence should serve as a stern warning for those selling counterfeit pharmaceuticals over the Internet," said Claude Arnold, special agent in charge of Homeland Security investigations in Los Angeles. ALSO: New task force unveiled to address LAFD response times Steve Lopez: Boy Scouts' ban on gays, bigotry over values Ex-lover will help San Fernando councilwoman beat battery charge Robert J. Lopez See more here: Man gets 1 year for selling fake erectile dysfunction pills … Continue reading →

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Prison for seller of fake erectile dysfunction drugs

Posted: Published on July 18th, 2012

A Canoga Park man who pleaded guilty to peddling counterfeit erectile dysfunction drugs has been sentenced to a year in prison and another year in home detention, federal authorities said Tuesday. Barry Ronnel Johnson, 38, was sent to prison Monday by U.S. District Judge Christina A. Snyder, who also ordered home detention upon his release. Johnson pleaded guilty in March to using Craigslist to peddle fake erectile dysfunction drugs from India and China after a probe by U.S. Immigration and Custom Enforcement. "This sentence should serve as a stern warning for those selling counterfeit pharmaceuticals over the Internet," said Claude Arnold of the agency's Homeland Security Investigations, in a statement. "Imposter drugs like these pose a serious threat to buyers who mistakenly assume (they're) safe." In March 2011, federal agents at Los Angeles International Airport intercepted a package containing 1,700 counterfeit erectile dysfunction pills posted to Johnson's Canoga Park home. He later sold 30 blue diamond-shaped tablets dubbed "Filagra" to an HSI undercover agent on Craigslist. See the original post: Prison for seller of fake erectile dysfunction drugs … Continue reading →

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Researchers identify mechanisms that allow embryonic stem cells to become any cell in the human body

Posted: Published on July 18th, 2012

(Phys.org) -- New research at the Hebrew University of Jerusalem sheds light on pluripotencythe ability of embryonic stem cells to renew themselves indefinitely and to differentiate into all types of mature cells. Solving this problem, which is a major challenge in modern biology, could expedite the use of embryonic stem cells in cell therapy and regenerative medicine. If scientists can replicate the mechanisms that make pluripotency possible, they could create cells in the laboratory which could be implanted in humans to cure diseases characterized by cell death, such as Alzheimer's, Parkinson's, diabetes and other degenerative diseases. To shed light on these processes, researchers in the lab of Dr. Eran Meshorer, in the Department of Genetics at the Hebrew Universitys Alexander Silberman Institute of Life Sciences, are combining molecular, microscopic and genomic approaches. Meshorer's team is focusing on epigenetic pathwayswhich cause biological changes without a corresponding change in the DNA sequencethat are specific to embryonic stem cells. The molecular basis for epigenetic mechanisms is chromatin, which is comprised of a cell's DNA and structural and regulatory proteins. In groundbreaking research performed by Shai Melcer, a PhD student in the Meshorer lab, the mechanisms which support an open chromatin conformation in embryonic … Continue reading →

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Mediware Acquisition Gains Market Momentum by Adding Major New Customer

Posted: Published on July 18th, 2012

LENEXA, Kan., July 17, 2012 (GLOBE NEWSWIRE) -- Mediware Information Systems, Inc. (MEDW) announced today that the global cord blood therapeutic company, Stemcyte, has licensed the Transtem cell therapy software to automate manufacturing processes associated with the company's cord blood collection and storage business. The Transtem software provides automated controls to streamline collection, testing and manufacturing processes for cord blood and adult stem cell products used in the treatment of cancer, blood diseases and research. Mediware announced the acquisition of Transtem on January 4, 2012 as part of its strategy to expand its focus from blood management to cellular therapy. A webcast featuring the Transtem capabilities for cord blood collection and processing is scheduled for July 18 and July 31 at 10 a.m. CDT (register online). With operations in the United States, India and Taiwan, Stemcyte has more than 50,000 cord blood units in its public and private inventories and is in the process of applying for licensure with the United States Food and Drug Administration (USFDA). The company is planning to leverage Transtem to improve donor recruitment and institute new controls in the company's manufacturing processes, both of which are needed to support their plans for efficient growth and … Continue reading →

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Gold Coast doctor sanctioned for steroid prescriptions

Posted: Published on July 18th, 2012

A Gold Coast doctor has inappropriately prescribed medications, including steroids, to 14 patients. An official investigation into anabolic steroid use on the Gold Coast has netted a long-standing GP, who inappropriately prescribed the drugs to 14 patients over more than nine years. Peter Grant, who faces sanctions, has practised as a GP in Queensland since 1985. In late 2009, Queensland Health cancelled his power to prescribe some classes of restricted drugs after the department investigated the GP's practice of writing scripts for medications "for body building rather than therapeutic purposes". Dr Grant's activities came to light when the department conducted a state-wide audit of the dispensing of pseudoephedrine. Advertisement At the same time, the department was conducting an ongoing investigation into anabolic steroid use in the Gold Coast area. Dr Grant agreed he had inappropriately prescribed medications to 14 patients at the Mermaid Beach Medical Centre, according to Queensland Civil and Administrative Tribunal deputy president Judge Fleur Kingham's recent ruling. The earliest allegation dated back to February 2000, when Dr Grant took on a new patient. "In all he treated him for more than nine years, until April 2009," according to Judge Kingham. Continue reading here: Gold Coast doctor sanctioned … Continue reading →

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New diet drug approved by FDA

Posted: Published on July 18th, 2012

Meg Evans, in red, lost 48 pounds her first year on Qsymia and another two pounds the second year. STORY HIGHLIGHTS (CNN) -- The U.S. Food and Drug Administration approved a new prescription diet drug called Qsymia on Tuesday. The medication produced dramatic weight loss in clinical trials, but some are concerned over potential side effects, including increased heart rate, birth defects and other issues. Qsymia (pronounced kyoo-SIM-ee-uh) is the second diet drug approved this year. The FDA approved a weight-loss pill called Belviq on June 27. Qsymia had been known as Qnexa until its approval. The FDA asked the company to change the name to avoid confusion with another drug on the market, according to the company. Patients in clinical trials experienced more dramatic weight loss with Qsymia than with Belviq. On Qsymia, patients went from an average 227 pounds to 204 pounds; on Belviq, the average weight dropped from 220 to 207. Some consumer advocates worry that the weight loss comes with a price. Some patients in the clinical trial suffered an increased heart rate and a condition called metabolic acidosis, which can lead to hyperventilation, fatigue and anorexia. Concerns have also been raised about birth defects. One … Continue reading →

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