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Multiple Sclerosis Drugs May Not Delay Disability

Posted: Published on July 18th, 2012

Interferon Beta Treatment Did Not Slow Progression of Disability in Study July 17, 2012 -- Disease-modifying drugs have been game-changers for the treatment of multiple sclerosis. The drugs help prevent relapses, but now new research questions whether they slow progression of disability from the disease. In a study of patients with relapsing-remitting MS, published in the Journal of the American Medical Association, use of the most widely prescribed disease-modifying drugs, interferon beta, was not associated with a delay in disability progression. Patients treated with interferon beta were no less likely than untreated patients to progress to the point where they required a cane to walk, which is a benchmark measure of disease progression. "Treatment with beta interferon was not associated with a delay in progression to disability," says researcher Helen Tremlett, PhD, of the University of British Columbia. "It may be that in subgroups of patients these drugs do slow disease progression, but we were not able to show this." As many as 2.5 million people worldwide and 350,000 people in the U.S. have multiple sclerosis, a progressive disease of the central nervous system that leaves most patients functionally disabled within a decade or two of diagnosis. In 1993, the … Continue reading →

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Pharmacy dean to step down in September 2013

Posted: Published on July 18th, 2012

Jeanette Roberts, dean of the UW-Madison School of Pharmacy, says the public policy and political sides of health care have always interested her. After a 10-year run as the head of the UW Systems only pharmacy school, Roberts plans to step aside next year to pursue that passion. Roberts Roberts announced this week that she will step down as dean effective Sept. 1, 2013. Roberts was named pharmacy schools dean in June 2003 after spending 15 years as an academic administrator and professor at the University of Utah College of Pharmacy. Provost Paul M. DeLuca Jr. praised Roberts for her leadership and vision. Under the guidance of Dean Roberts, the School of Pharmacy has continued to build on its reputation as a premier institution on a global scale, and a critical component of the health care system in the state of Wisconsin, DeLuca says. The most recent U.S. News rankings of pharmacy programs put UWMadisons fifth among more than 100, up from ninth the previous year and ahead of programs at Ohio State University and the University of Michigan. In addition, the World Education Congress recently named the school Best Educational Institute in Pharmacy in the world. The school would … Continue reading →

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Research and Markets: Pharmacy Retailing in the UK: A Must-Read Report Exploring Market Trends, Opportunities And …

Posted: Published on July 18th, 2012

DUBLIN--(BUSINESS WIRE)-- Research and Markets (http://www.researchandmarkets.com/research/ndd9f8/pharmacy_retailing) has announced the addition of the "Pharmacy Retailing in the UK | Verdict Market Report" report to their offering. With an ageing population, significant changes in government policy and consolidation in the market, Pharmacy is an ever-changing sector. Learn where the opportunities and threats are in the market and how to manage these most effectively for your business.Reduce the impact of changes in government policy on your business by being prepared and understanding where the greatest threats will come from.Use the data, forecasts to 2015, and insight on the market, including NHS receipts and OTC, to help form an effective growth strategy. Understand the impact on pharmacy retailing of the Boots/Walgreens merger and how the investment will increase competitiveness in the sector.Identify the opportunities to grow business in this sector by comparing strategies of the key players in the market and their performance metrics.In 2011, the government announced plans for changes in the control of entry rules that would end the 100 hours exemption and this has prompted a rush of opening applications which we forecast will dilute profitability. 250 new pharmacies opened in the first four months of 2012.Furthermore price deflation is making … Continue reading →

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Guardian Pharmacy CEO and Founder, Fred Burke, Named Regional Ernst & Young Entrepreneur of the Year® 2012

Posted: Published on July 18th, 2012

ATLANTA--(BUSINESS WIRE)-- Guardian Pharmacy, LLC, one of the largest long-term care pharmacy companies in the U.S., announced that Fred Burke, CEO and co-founder, received the Ernst & Young Entrepreneur of the Year 2012 Alabama/Georgia/Tennessee Award in the Healthcare category. This highly coveted and prestigious award recognizes entrepreneurs who demonstrate excellence and extraordinary success in areas such as innovation, financial performance and personal commitment to their businesses and communities. Id like to thank Ernst & Young for highlighting and honoring the profession of entrepreneurship, which means a lot to those of us who consider this our chosen profession, said Burke. We are especially pleased to be honored because our business model serves as an incubator for local entrepreneurs, and its success is the result of the diligence and vision of the entire Guardian team. Founded in 2004 by Fred Burke, Kendall Forbes and David Morris, Guardian Pharmacy LLC has grown from 70 to more than 800 professionals. The company recently completed a record-breaking 2011 adding five new pharmacies and boosting revenue 35 percent over 2010. The combined Guardian entity serves more than 40,000 long-term care patients nationally through 20 pharmacies across 12 states. Additionally, the company has been recognized as one … Continue reading →

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Targeted Medical Pharma Issues Letter to Shareholders

Posted: Published on July 18th, 2012

LOS ANGELES--(BUSINESS WIRE)-- Targeted Medical Pharma, Inc., a specialty pharmaceutical company that develops and distributes prescription medical foods to physicians, pharmacies and skilled nursing facilities, today issued the following letter to shareholders from its Chairman and Chief Executive Officer and Chief Scientific Officer, William Shell, M.D. Dear Fellow Shareholders: If one word can best characterize the past year for me and for Targeted Medical Pharma, that word would be change. It has been a fast-paced journey for all of us, marked by substantial growth that places our company on the cusp of formidable transformation. There was great progress positioning us for the introduction of promising new products, having filed multiple new patents, completing clinical trials of a treatment for Post-Traumatic Stress Disorder (PTSD) and developing an advanced obesity management system. As we enter the second half of 2012, our team is excited about the research that is now well underway on a technology, believed to be the first of its kind, for stem cell stimulation via an oral administration. As of this writing, our employee count has grown to 68 full time employees, with more than 40 direct and indirect sales representatives in our own sales force and those of … Continue reading →

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Researchers turn skin cells into brain cells, a promising path to better Parkinson's treatment

Posted: Published on July 18th, 2012

ScienceDaily (July 17, 2012) Using adult stem cells, Johns Hopkins researchers and a consortium of colleagues nationwide say they have generated the type of human neuron specifically damaged by Parkinson's disease (PD) and used various drugs to stop the damage. Their experiments on cells in the laboratory, reported in the July 4 issue of the journal Science Translational Medicine, could speed the search for new drugs to treat the incurable neurodegenerative disease, but also, they say, may lead them back to better ways of using medications that previously failed in clinical trials. "Our study suggests that some failed drugs should actually work if they were used earlier, and especially if we could diagnose PD before tremors and other symptoms first appear," says one of the study's leaders, Ted M. Dawson, M.D., Ph.D., a professor of neurology at the Johns Hopkins University School of Medicine. Dawson and his colleagues, working as part of a National Institute of Neurological Disorders and Stroke consortium, created three lines of induced pluripotent stem (iPS) cells derived from the skin cells of adults with PD. Two of the cell lines had the mutated LRKK2 gene, a hallmark of the most common genetic cause of PD. Induced … Continue reading →

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StemCells, Inc. Announces Its Human Neural Stem Cells Restore Memory in Models of Alzheimer's Disease

Posted: Published on July 18th, 2012

NEWARK, Calif., July 17, 2012 (GLOBE NEWSWIRE) -- StemCells, Inc. (STEM), today announced preclinical data demonstrating that its proprietary human neural stem cells restored memory and enhanced synaptic function in two animal models relevant to Alzheimer's disease (AD). The data was presented today at the Alzheimer's Association International Conference 2012 in Vancouver, Canada. The study results showed that transplanting the cells into a specific region of the brain, the hippocampus, statistically increased memory in two different animal models. The hippocampus is critically important to the control of memory and is severely impacted by the pathology of AD. Specifically, hippocampal synaptic density is reduced in AD and correlates with memory loss. The researchers observed increased synaptic density and improved memory post transplantation. Importantly, these results did not require reduction in beta amyloid or tau that accumulate in the brains of patients with AD and account for the pathological hallmarks of the disease. The research was conducted in collaboration with a world-renowned leader in AD, Frank LaFerla, Ph.D., Director of the University of California, Irvine (UCI) Institute for Memory Impairments and Neurological Disorders (UCI MIND), and Chancellor's Professor, Neurobiology and Behavior in the School of Biological Sciences at UCI. Matthew Blurton-Jones, Ph.D., … Continue reading →

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Stem-cell discovery: reversing Alzheimer's?

Posted: Published on July 18th, 2012

Human neural stem cells. Courtesy UC Irvine radiation oncology professor Charles Limoli. Human neural stem cells restored memory in mice with brain symptoms similar to Alzheimers disease, UC Irvine scientists reported Tuesday, opening the door to eventual treatment for human sufferers. The announcement, made at an Alzheimers science conference in Vancouver, involves versatile though still largely mysterious neural stem cells grown in the lab by StemCells Inc., of Newark, Ca. The cells, researchers at UCI and elsewhere have shown, can become many types of cells once injected into the body restoring limb movement in mice with crushed spines, halting blindness in rats and, now, improving memory and brain function in mice bred to exhibit the kinds of impairment seen in Alzheimers. Youve probably heard about the God particle scientists have been working on, said Martin McGlynn, president and CEO of StemCells Inc. This isnt quite the God cell, but its an incredibly fascinating biological agent. Over the past 12 to 18 months, scientists including Frank LaFerla, director of UCI MIND, worked on a treatment involving injection of the human neural stem cells into the brains of two kinds of mouse models those bred to model the effects of Alzheimers, and … Continue reading →

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The real life spider men: researchers create potential treatment for muscular dystrophy from the venom of a tarantula

Posted: Published on July 18th, 2012

Discovery could prolong life of sufferers by decades Chemical in spider venom key to new therapy Firm to create treatments already set up By Mark Prigg PUBLISHED: 10:34 EST, 17 July 2012 | UPDATED: 10:36 EST, 17 July 2012 She may look like any other giant spider, but scientists say Rosie, a Chilean rose tarantula, may actually hold the key to treating muscular dystrophy. The spider started out as a pet for Professor Frederick Sachs of the University at Buffalo. However, he discovered a key chemical in the venom of the spider can fool the body into thinking it is under attack and cause it to beat the disease. Even Professor Sachs admits the therapy is unusual. 'No one in their right mind would give spider spit to a kid with dystrophy,' he said. 'It's only through the basic science that you can end up here. If you keep your eyes open, you see things you would never have looked for.' Researchers are developing a treatment for muscular dystrophy using a chemical found in the venom of a Chilean rose tarantula More: The real life spider men: researchers create potential treatment for muscular dystrophy from the venom of a tarantula … Continue reading →

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New evidence links immune irregularities to autism, mouse study suggests

Posted: Published on July 18th, 2012

ScienceDaily (July 17, 2012) Scientists at the California Institute of Technology (Caltech) pioneered the study of the link between irregularities in the immune system and neurodevelopmental disorders such as autism a decade ago. Since then, studies of postmortem brains and of individuals with autism, as well as epidemiological studies, have supported the correlation between alterations in the immune system and autism spectrum disorder. What has remained unanswered, however, is whether the immune changes play a causative role in the development of the disease or are merely a side effect. Now a new Caltech study suggests that specific changes in an overactive immune system can indeed contribute to autism-like behaviors in mice, and that in some cases, this activation can be related to what a developing fetus experiences in the womb. The results appear in a paper this week in the Proceedings of the National Academy of Sciences (PNAS). "We have long suspected that the immune system plays a role in the development of autism spectrum disorder," says Paul Patterson, the Anne P. and Benjamin F. Biaggini Professor of Biological Sciences at Caltech, who led the work. "In our studies of a mouse model based on an environmental risk factor for … Continue reading →

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