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Orlando Health Uses Polycom® RealPresence® Mobile 1.3 Video Collaboration to Allow Neurologists to Speed Stroke …

Posted: Published on July 17th, 2012

SAN JOSE, Calif.--(BUSINESS WIRE)-- Polycom, Inc. (PLCM), the global leader in open standards-based unified communications, today announced that Orlando Health is responding much more quickly to stroke alerts by using Polycom RealPresence Mobile and other Polycom video collaboration solutions. Time is of the essence when a patient has suffered a stroke, and treatment must be administered within a narrow window of time to minimize the likelihood of brain damage. Polycom video collaboration allows neurologists working offsite, whether in another hospital or at home, to conduct thorough assessments of stroke victims and initiate treatment faster. Polycom RealPresence Mobile just made it even easier with its new remote, far-end camera control feature that equips neurologists with a way to examine patients in closer detail by controlling what they can see on the patient directly from their tablet or device, such as the pupils of the patients eyes. (Watch the related video; see related RealPresence Mobile 1.3 press release; and see announcement on significant enhancements to the Polycom RealPresence Platform for enterprises.) Treating Stroke Patients Sooner Improves Outcome According to the Centers for Disease Control and Prevention, stroke is the fourth-leading cause of death in the United States. Someone in the U.S. suffers … Continue reading

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Neurons Derived From Cord Blood Cells May Represent New Therapeutic Option

Posted: Published on July 17th, 2012

Protocol may open new avenues for cell-replacement therapies for neurological conditions Newswise LA JOLLA, CA----For more than 20 years, doctors have been using cells from blood that remains in the placenta and umbilical cord after childbirth to treat a variety of illnesses, from cancer and immune disorders to blood and metabolic diseases. Now, scientists at the Salk Institute for Biological Studies have found a new way-using a single protein, known as a transcription factor-to convert cord blood (CB) cells into neuron-like cells that may prove valuable for the treatment of a wide range of neurological conditions, including stroke, traumatic brain injury and spinal cord injury. The researchers demonstrated that these CB cells, which come from the mesoderm, the middle layer of embryonic germ cells, can be switched to ectodermal cells, outer layer cells from which brain, spinal and nerve cells arise. "This study shows for the first time the direct conversion of a pure population of human cord blood cells into cells of neuronal lineage by the forced expression of a single transcription factor," says Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory, who led the research team. The study, a collaboration with Fred H. Gage, a … Continue reading

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What would you do if your child is diagnosed with cancer?

Posted: Published on July 17th, 2012

By Benita Aw Yeong The New Paper Tuesday, Jul 17, 2012 SINGAPORE - When she first heard that her young daughter was diagnosed with cancer, Ms Cynthia Lim's knee-jerk reaction towards chemotherapy was a visceral and immediate "no". "There was the shock of having to deal with the disease. Then there was a bit of denial, which made it difficult to be rational," says the 32-year-old, whose four-year-old daughter Charmaine died from neuroblastoma last October. "For someone who did not have previous exposure to cancer, the pre-conceived notions about the side effects of chemo were so deeply ingrained in me that I just did not want her to go through that." Charmaine (right) would have turned seven yesterday. Eventually, Ms Lim came around to the idea that her child needed to undergo the treatment. After reading voraciously about the disease six months after the initial diagnosis, Ms Lim realised chemotherapy was the only chance for her daughter against cancer. The New Paper on Sunday approached Ms Lim after The Straits Times reported on Tuesday about a mother who objected to chemotherapy for her leukaemia-stricken son. The 31-year-old prefers "natural therapies" at an alternative health and well-being centre in the US … Continue reading

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LSUHSC research finds treating stress prevented new MS brain lesions

Posted: Published on July 17th, 2012

Public release date: 16-Jul-2012 [ | E-mail | Share ] Contact: Leslie Capo lcapo@lsuhsc.edu 504-568-4806 Louisiana State University Health Sciences Center New Orleans, LA Research conducted by Jesus Lovera, MD, Assistant Professor of Neurology at LSU Health Sciences Center New Orleans, and colleagues has shown that stress management treatment significantly reduced the formation of new brain lesions in people with multiple sclerosis (MS) over the course of treatment. These lesions are markers of disease activity used to objectively measure disease status. The work is published ahead of print and is now available online in Neurology. "Our research found that 77% of the patients undergoing stress management therapy remained free of lesions while they were in treatment compared to 55% of those in the control group," notes Dr. Jesus Lovera, an LSU Health Sciences Center New Orleans board certified neurologist whose research and practice focus on multiple sclerosis. The research team studied 121 patients with relapsing forms of MS, most of whom are women. They were randomly assigned to receive stress management therapy for MS or were wait-listed while continuing to receive their usual treatment for MS. The therapy group received 16 individual treatment sessions over 24 weeks, and were then … Continue reading

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The path from stem cell to maturity

Posted: Published on July 17th, 2012

Regulation of gene expression is essential to make sure cell maturation occurs as it should. European research is taking an integrated perspective on how selected steps in liver and blood cell differentiation can be modulated. Gene regulation mechanisms are active at every level of development, from the passage of stem cell through to differentiated cell. On from there to maintenance of identity of the mature, functioning cell, regulation is maintained through cellular memory mechanisms. The "Integrated approaches to study gene regulation during cellular differentiation" (Integer) project is aiming to investigate all levels of gene regulation with a multidisciplinary and integrated approach to research. Specifically, during cell differentiation study, regulation of trans-acting factors and genetic material has come under the microscope. Protocols established by Integer include 4C or 3C ChIP sequencing and RNA-binding protein immunoprecipitation (RIP) sequencing. For visualising intra-nuclear associations, cryo-FISH imaging techniques were used. Appropriate cell lines were established for the planned genomic work and, to analyse the sequencing data, software tools were refined and optimised. The main achievement of the Integer project to date is the characterisation of binding patterns in differentiating liver and red blood cells. Several novel genes were identified that are regulated by these factors. … Continue reading

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Stem cell discovery important for cancer

Posted: Published on July 17th, 2012

THE discovery of a unique marker on stem cells from the gut, liver and pancreas could eventually allow scientists to diagnose cancer earlier and develop new treatments, a Melbourne scientist says. Professor Martin Pera from Stem Cells Australia and an international team developed an antibody that identifies and isolates the marker, which sits on the outer surface of stem cells and another type of cell called a progenitor. These cells are particularly hard to find in the pancreas and liver. By identifying the markers, the cells can be isolated and extracted for study in the laboratory, where scientists can observe what happens to the cells during the disease process and in repair and regeneration. Prof Pera, who is also chair of Stem Cell Sciences at the University of Melbourne, said the number of cells with the marker expanded during pancreatic and esophageal cancer, and liver cirrhosis. "It may well be that they are precursors of the cancers," Prof Pera told AAP. He said if the marker could be found in the blood of cancer patients, it could allow sufferers to be diagnosed earlier and provide new approaches to treatment, which could involve developing drugs to target the marker on cancer … Continue reading

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New York Stem Cell Foundation scientists featured for new model of Alzheimer's disease

Posted: Published on July 17th, 2012

Public release date: 16-Jul-2012 [ | E-mail | Share ] Contact: David McKeon dmckeon@nyscf.org 212-365-7440 New York Stem Cell Foundation NEW YORK, NY (July 16, 2012) A team of scientists at The New York Stem Cell Foundation (NYSCF) Laboratory led by Scott Noggle, PhD, NYSCFCharles Evans Senior Research Fellow for Alzheimer's Disease, has developed the first cell-based model of Alzheimer's disease (AD) by reprogramming skin cells of Alzheimer's patients to become brain cells that are affected in Alzheimer's. This will allow researchers to work directly on living brain cells suffering from Alzheimer's, which until now had not been possible. Andrew Sproul, PhD, a postdoctoral associate in Dr. Noggle's laboratory, will present this work on Thursday, July 19 at the Alzheimer's Association International Conference (AAIC) held in Vancouver. Dr. Noggle and his team reprogrammed skin cell samples taken from twelve patients diagnosed with early-onset Alzheimer's and from healthy, genetically related individuals into induced pluripotent stem (iPS) cells, which can differentiate into any cell type. The team of scientists used these iPS cells to create cholinergic basal forebrain neurons, the brain cells that are affected in Alzheimer's. These cells recapitulate the features and cellular-level functions of patients suffering from Alzheimer's, a devastating … Continue reading

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Oracle Health Sciences Translational Research Center to Support Cancer Research UK's Development of Targeted Cancer …

Posted: Published on July 17th, 2012

REDWOOD SHORES, CA -- (Marketwire) -- 07/16/12 -- Oracle (NASDAQ: ORCL) News Facts To support its vision of beating cancer in the United Kingdom, Cancer Research UK, the world's largest not-for-profit cancer research organization, will be working with Oracle Health Sciences Translational Research Center as the foundation for a new analytical environment that will help the charity combine the genetic and clinical data from its Stratified Medicine Programme. Together with AstraZeneca, Pfizer and the UK government's Technology Strategy Board, Cancer Research UK is working to demonstrate a national service that will provide standardized, high-quality and cost-effective genetic testing of tumors linked to clinical data. This system has already tested two thousand tumors from patients across 24 clinical sites, and set up data capture covering diagnostics, genetics, treatment and outcomes. Cancer Research UK will use Cohort Explorer which is part of the Oracle Health Sciences Translational Research Center to create a flexible, web-accessible analytical platform and interface that enables program affiliates to effectively and rapidly search and retrieve anonymized diagnostic, treatment and outcome data to accelerate research. The platform will enable researchers and physicians to gain the insight needed to identify patient populations with similar characteristics and advance personalized cancer treatments. … Continue reading

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Acquisition of Navigenics Expands Life Technologies' Capabilities in Diagnostics

Posted: Published on July 17th, 2012

CARLSBAD, Calif., July 16, 2012 /PRNewswire/ -- Life Technologies Corporation (LIFE) today announced the acquisition of Navigenics, Inc. This acquisition represents Life Technologies' first step in executing against a strategy to build out its molecular diagnostics business through internal development, partnerships and select acquisitions. "Genetic analysis is becoming increasingly accessible, cost-effective and a critical part of patient clinical management," said David Agus, M.D. co-founder of Navigenics, professor of Medicine and Engineering at the University of Southern California, and author of The End of Illness. "As a result, physicians have more complete and accurate information about the patient than ever before, which is translating into more effective, individualized care programs for patients." "The advent of personalized medicine will require a combination of technologies and informatics focused on delivering relevant information to the treating physician," said Ronnie Andrews, president of Medical Sciences at Life Technologies. "Navigenics has pioneered the synthesis and communication of complex genomic information, and we will now pivot the company's effort to date and focus on becoming a comprehensive provider of technology and informatics to pathologists and oncologists worldwide." Navigenics' multidisciplinary expertise, including its technology infrastructure, user interfaces, online platforms, genomic support services, and an experienced team, will play … Continue reading

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'Nanorobot' can be programmed to target different diseases

Posted: Published on July 17th, 2012

(Phys.org) -- University of Florida researchers have moved a step closer to treating diseases on a cellular level by creating a tiny particle that can be programmed to shut down the genetic production line that cranks out disease-related proteins. In laboratory tests, these newly created nanorobots all but eradicated hepatitis C virus infection. The programmable nature of the particle makes it potentially useful against diseases such as cancer and other viral infections. The research effort, led by Y. Charles Cao, a UF associate professor of chemistry, and Dr. Chen Liu, a professor of pathology and endowed chair in gastrointestinal and liver research in the UF College of Medicine, is described online this week in the Proceedings of the National Academy of Sciences. This is a novel technology that may have broad application because it can target essentially any gene we want, Liu said. This opens the door to new fields so we can test many other things. Were excited about it. During the past five decades, nanoparticles particles so small that tens of thousands of them can fit on the head of a pin have emerged as a viable foundation for new ways to diagnose, monitor and treat disease. Nanoparticle-based … Continue reading

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