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Novelos Therapeutics Announces Positive Initial Imaging Results In Brain Cancer Trial With I-124-CLR1404 (LIGHT …

Posted: Published on June 20th, 2012

MADISON, Wis., June 19, 2012 /PRNewswire/ -- Novelos Therapeutics, Inc. (NVLT), a pharmaceutical company developing novel drugs for the treatment and diagnosis of cancer, today announced that the University of Wisconsin Carbone Cancer Center (UWCCC), a leading oncology research institution, has successfully dosed three patients in a Phase 1-2 positron emission tomography (PET) imaging trial of I-124-CLR1404 (LIGHT), a cancer-targeted PET imaging agent, in patients with primary or metastatic brain cancer. The three glioma patients were dosed with LIGHT at 5 mCi. Details of the trial design are available at http://www.clinicaltrials.gov ID: NCT01540513, or at http://www.novelos.com in the 'Clinical Trials' section. Lance Hall, M.D., is the trial's principal investigator. This trial is being funded by the UWCCC and the Institute for Clinical and Translational Research (ICTR). Detailed trial results are expected to be presented at a scientific venue at a later date. "Despite recent advances in diagnostic and therapeutic techniques, prognosis of patients with many brain tumors, and particularly malignant gliomas, remains dismal. This reflects in part the diagnostic uncertainty in identifying infiltrative tumor growth of malignant gliomas which in turn affects subsequent treatment strategies," said Dr. Hall. "The preliminary results from these three glioma patients are very encouraging. We … Continue reading

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Neuralstem Pioneering Efforts In ALS – Analyst Blog

Posted: Published on June 20th, 2012

By Jason Napodano, CFA Neuralstem, Inc. (NYSE MKT: CUR ) has developed a technology that allows large-scale expansion of human neural stem cells ("hNSC") from all areas of the developing human brain and spinal cord. The company owns of has exclusive license to 25 patients and 29 patent applications pending worldwide in the field of regenerative medicine and cell therapy. Management is currently focusing the company's efforts on replacing damaged, malfunctioning, or dead neural cells with fully functional ones that may be useful in treating many central nervous system diseases and neurodegenerative disorders. Neuralstem's lead development program is for Amyotrophic Lateral Sclerosis ("ALS"), also known as Lou Gehrig 's disease, named after the famous New York Yankee first baseman who was diagnosed with the disease in 1939, and passed in 1941 at the age of only 37. ALS Background ALS is a rapidly progressive neurodegenerative disease characterized by weakness, muscle atrophy and twitching, spasticity, dysarthria (difficulty speaking), dysphagia (difficulty swallowing), and respiratory compromise. The disease is almost always fatal, typically due to respiratory compromise or pneumonia, in two to four years. Initial symptoms of ALS include weakness and/or stiffness followed by muscle atrophy in the arms and legs. This is … Continue reading

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CUR – Neuralstem Pioneering Efforts In ALS

Posted: Published on June 20th, 2012

As of now, management is planning to conduct the pivotal program on its own, mostly likely seeking funding through grants with the ALS Association and U.S. National Institutes of Health. However, management is also in discussion with potential pharmaceutical partners on the pivotal program. ALS is a highly attractive area for Big Pharma. Depending on the strength of the phase 1 / 2 data, Neuralstem may be able to strike a commercialization partnership in 2014 to help defer the costs of the planned pivotal trial. We expect that any deal with a larger pharmaceutical company would include a substantial upfront payment that Neuralstem would then use to fund expansion of the development platform into new indications, such as spinal cord injury (IND filed) or stroke. Market Opportunity In February 2011, the U.S. FDA granted Neuralstem an Orphan Drug designation for its human spinal cord stem cells (HSSC) for the treatment of ALS. As noted above, there are approximately 30,000 patients in the U.S. living with ALS. We estimate that approximately half of these patients are characterized with an FVC > 60% and may be eligible for treatment with Neuralstems hNSCs. Given the Orphan Drug designation, the limited patient population, and … Continue reading

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Philip Salvador, kakalabanin ang kaibigang aktor!

Posted: Published on June 20th, 2012

TO A great extent, the latest medical breakthrough called stem cell treatment has swept the nation like a typhoon entering the Philippine area of responsibility (or PAR as weather experts would say). Previously in our column here in Pinoy Parazzi ay iniulat na namin ang lumalakas na pananampalataya in this modern science na bagamat maaaring gawin sa bansa ay mas epektibo kung sasailalim ang pasyente sa prosesong ito sa mismong bansa ang Germany na siyang pinagkukunan ng anti-aging substance extracted from a black mountain sheep. By now, Boy Abunda must have left for Germany with his Nanay Lising whos suffering dementia (or Alzheimers disease) na karaniwan namang dumadapo sa mga taong may edad na. Also, in a week or two ay tutungo rin si Lolit Solis sa naturang bansa for treatment of her diabetes (pero sagot ni Dra. Vicki Belo ang isang milyong pisong bayad) with her ward Lorna Tolentino na siyang maglilibre naman ng kanilang week-long stay roon. Minsan nang naipahayag ni Butch Francisco (who openly admits na wala siyang ganoong halaga after he had his condo unit in Greenhills repaired, almost reconstructed) na paano na raw ang mahihirap who cannot afford to avail of stem cell treatment? Wala … Continue reading

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Sixteenth Patient Dosed In Neuralstem ALS Stem Cell Trial

Posted: Published on June 20th, 2012

ROCKVILLE, Md., June 19, 2012 /PRNewswire/ --Neuralstem, Inc. (NYSE MKT: CUR) announced that the first patient to receive stem cell transplantation in both regions of the spinal cord has been treated in the ongoing Phase I trial of its spinal cord neural stem cells in amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease). This is also the 16th patient to be treated in the trial altogether and the first patient returning to the trial for a second treatment. In this treatment, the patient received five injections in the cervical (upper back) region of the spinal cord, in addition to the ten he received previously in the lumbar (lower back) region of the spine, for a total of 15 injections. This is the highest number of injections in the trial so far. Patient 16 is also the first patient in the world to receive stem cell transplants in both the lumbar and cervical regions of the spinal cord in an FDA-approved trial. Two additional previously-treated patients are expected to return to the trial this summer in this cohort, provided they continue to meet the inclusion requirements. The trial is taking place at Emory University Hospital in Atlanta, Georgia. (Logo: http://photos.prnewswire.com/prnh/20061221/DCTH007LOGO ) … Continue reading

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Metformin treatment caused cancer stem cell death in pancreatic cancer cell lines

Posted: Published on June 20th, 2012

Public release date: 19-Jun-2012 [ | E-mail | Share ] Contact: Jeremy Moore jeremy.moore@aacr.org 215-446-7109 American Association for Cancer Research LAKE TAHOE, Nev. Results of some preclinical trials have shown that low doses of the antidiabetic drug metformin may effectively destroy cancer stem cells, a group of cells that are considered to be responsible for tumor initiation and, because they are resistant to standard chemotherapies, tumor relapse. In addition, when metformin was combined with a standard chemotherapy used for pancreatic cancer, the combination treatment was able to efficiently eradicate both cancer stem cells and more differentiated cancer cells, which form the bulk of the tumor, according to data presented by Christopher Heeschen, M.D., Ph.D., at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held in Lake Tahoe, Nev., from June 18-21, 2012. Heeschen is professor for experimental medicine at the Spanish National Cancer Research Centre in Madrid, Spain. Most clinical trials of pancreatic cancer conducted during the last 15 years have failed to show marked improvement in median survival, suggesting that the selected approaches were not sufficient for several reasons, according to Heeschen. In recent years, researchers have identified cancer stem cells which, as opposed to … Continue reading

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Dr. Manny: Autism drugs on the way, but be careful

Posted: Published on June 20th, 2012

According to recent news reports, pharmaceutical giants like Roche, Novartis, and Seaside Therapeutics are racing to make medications that will relieve some of the behavioral problems caused by autism and Fragile X syndrome. The first thing that needs to be cleared up is that autism or the autistic spectrum, which might include pervasive developmental disorders or Asperger syndrome is different from Fragile X syndrome. Fragile X is an inherited intellectual disability in boys that is caused by a change in the gene FMR1 on the X chromosome. The condition results in the failure to express FMRP a protein needed for normal neural development. While Fragile X syndrome has similar symptoms to autism, it differs in that it has a very well described genetic underpinning. The reason this is important is because medications for the treatment of autism symptoms need to be carefully studied and individualized to specific spectrum disorders. If not approached in the right way, we may end up with medications that are perhaps not indicated properly and abused down the line. A specific medication that has gotten everyone excited is the drug arbaclofen. This drug has already been tested on small clinical trials, mostly in patients with Fragile … Continue reading

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First-Ever Canadian Guidelines on Parkinson's Disease to Lead to Consistent Diagnosis and Treatment Across Canada

Posted: Published on June 20th, 2012

TORONTO, ONTARIO--(Marketwire -06/19/12)- Parkinson Society Canada, in partnership with leading Canadian movement disorder specialists and neurologists, today launched the first Canadian Guidelines on Parkinson's Disease. The Guidelines aim to create, for the first time in Canada, a consistent standard for diagnosing and treating Parkinson's. The Guidelines provide health care professionals with practical, clinical advice for the diagnosis and treatment of Parkinson's, based on the best published evidence and on expert consensus. The 84 recommendations are designed primarily for family physicians, neurologists, and other health care professionals. The Canadian Guidelines on Parkinson's Disease will be published July 2012 in the Canadian Journal of Neurological Sciences and are available online today. The Guidelines have been endorsed by the Canadian Neurological Sciences Federation and Parkinson Society Canada. "Most Canadians with Parkinson's do not attend specialized Parkinson's or movement disorders clinics," says Dr. David Grimes, Director of the Ottawa Hospital's Parkinson's Disease and Movement Disorders Clinic and editor of the guidelines. "A tool was needed so that all health care providers who treat people with Parkinson's in Canada have a clear idea on how best to help individuals manage their disease. The guidelines are meant to improve the standard of care and access to … Continue reading

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Myrtle Beach woman treated for brain injury, police charge her boyfriend

Posted: Published on June 20th, 2012

A 46-year-old woman was treated for bleeding from her brain at a Charleston area hospital, and a Myrtle Beach man was charged with beating her, according to a police report. Thomas Edward Cooper, 38, is charged with criminal domestic violence of a high and aggravated nature and is being held at the Myrtle Beach Jail pending a bond hearing, according to jail records. Cooper was arrested at 4 p.m. Monday in the 200 block of 26th Avenue South, according to an arrest report. The charge stemmed from officers being called at 5:30 a.m. Sunday to Waccamaw Community Hospital where the victim sought treatment, police said. The victim told officers that about 7:30 p.m. Saturday she went to Coopers apartment and he accused her of cheating on him. The victim said Cooper, her boyfriend, pushed her, punched her in the face, repeatedly strangled her on the bed and would not allow her to leave the apartment, according to the report. The victim said she fought back, but it did not help her. The victim said a 62-year-old woman, who also was inside the apartment, provoked Cooper during the incident and pushed the victim down multiple times to keep her from leaving … Continue reading

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Progesterone may save traumatic brain injury patients

Posted: Published on June 20th, 2012

Contributor (888) 633-0360 A young woman has been given a second chance at life after a pedestrian accident that couldve left her an invalid with traumatic brain injury. Eighteen-year-old Michelle Vaquero wound up on the wrong side of a car while crossing the street. The was sent soaring 30 feet away from the initial contact. Doctors didnt give Michelles mom, Miriam, much optimism. The impact was so severe that they didnt give us any hope, she told the New York Times. They didnt tell us shed be fine. They didnt know how bad it was. Michelles mother had reason to worry since traumatic brain injury has been known to cause permanent disability and even death. According to the Centers for Disease Control and Prevention, each year, nearly 1.7 million Americans suffer some type of traumatic brain injury, which can range from mild to severe. In most cases people suffer from a mild traumatic brain injury, which are usually various forms of concussions. About 275,000 people are hospitalized annually, and about 50,000 die from the severity of the injury. Thanks to a medical study, Michelle may beat those odds. The Times reports that upon her arrival at the hospital, she was … Continue reading

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