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OMICS Group :: Journal of Cell Science

Posted: Published on June 8th, 2012

07-06-2012 07:39 Cell being the smallest part of any organism, is a building block of life. Cell therapies often focus on the treatment of hereditary diseases, with methods of gene therapy. The journal describes biology of a cell and the process of pioneering new cells into a tissue in order to negotiate a disease. Read more: OMICS Group :: Journal of Cell Science … Continue reading

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Mayo-Led Study Leads to Advanced Basal Cell Carcinoma Drug

Posted: Published on June 8th, 2012

Newswise SCOTTSDALE, Ariz. Its the most common form of skin cancer, but in its advanced stages, basal cell carcinoma has the potential to become disfiguring and life threatening. An international phase 2 study headed by Mayo Clinic led to the recent Food and Drug Administration approval of the first drug of its kind to help advanced basal cell carcinoma patients who have few treatment options. The results appear in the June 7 edition of the New England Journal of Medicine. The study found the drug Erivedge (vismodegib) shrank advanced basal cell carcinoma tumors in 43 percent of patients with locally advanced disease and in 30 percent of patients whose disease spread to other organs. This targeted therapy represents a new paradigm in cancer treatment, says lead researcher Aleksandar Sekulic, M.D., Ph.D., a dermatologist and cancer researcher at Mayo Clinic in Arizona. More than 2 million cases of basal and squamous cell skin cancer are found in this country each year. Basal cell carcinoma accounts for approximately 80 percent of all diagnosed non-melanoma skin cancers, according to the American Cancer Society. It occurs when a basal cell develops a mutation in its DNA, causing it to multiply rapidly, with the potential … Continue reading

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TiGenix: National Reimbursement in the Netherlands Obtained for Breakthrough Cartilage Therapy ChondroCelect(R)

Posted: Published on June 8th, 2012

LEUVEN, BELGIUM--(Marketwire -06/08/12)- TiGenix (EURONEXT:TIG) TiGenix obtains national reimbursement in the Netherlands for breakthrough cartilage therapy ChondroCelect TiGenix (EURONEXT:TIG) announced today that its innovative cartilage repair therapy ChondroCelect has obtained national reimbursement in the Netherlands. The Dutch National Health Authority (NZa) has formally announced that ChondroCelect is to receive national reimbursement retroactively per January 1, 2012. Previously ChondroCelect was made available in the Netherlands under a risk-sharing scheme. "We are delighted with the decision of the NZa to reimburse ChondroCelect, and look forward to working with Dutch orthopedic centers of excellence and health insurers to routinely make this breakthrough therapy available to the right patients in the Netherlands," said Eduardo Bravo, CEO of TiGenix. "Dutch clinicians and scientists have been instrumental in ChondroCelect's development and four Cartilage Expert Centers in the Netherlands have already gained extensive experience with the procedure. After having obtained national reimbursement in Belgium last year, this constitutes another major step in improving patient access to this innovative therapy. We remain optimistic that we can obtain national reimbursement in other European countries later this year." About TiGenix TiGenix NV (EURONEXT:TIG) is a leading European cell therapy company with a marketed product for cartilage repair, ChondroCelect, and a … Continue reading

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EK Health ‘Next Step’ Achieves Large Payer Savings in Workers’ Comp Cases Involving Narcotic Drugs

Posted: Published on June 8th, 2012

SAN JOSE, Calif.--(BUSINESS WIRE)-- With prescription drug abuse near epidemic proportions and the FDAs initiative to educate medical providers on the use of opioids, EK Health Services is well ahead of the curve. A national leader in medical and disability management services, EK Health through its Next Step Medical Advisory Program has created a track record for successfully transitioning injured employees from drug dependency to recovery. The proprietary program has shown measurable success in helping injured workers reclaim functionality and a productive life, while helping payers save substantial dollars in one of the most costly components of workers compensation medical claims drug expenditures. EK Health created the exclusive program to resolve stagnating workers compensation claims, especially those that are complex, costly and involve poly-pharmacy and potentially addictive pain medication. The programs approach helps insurance carriers, employers, injured workers and medical professionals by converting patients to less costly treatment alternatives that follow evidence-based medical guidelines, including ACOEM's Practice Guidelines, considered the gold standard in effective treatment of occupational injuries and illnesses. We developed the program in direct response to clients who asked for help with claims that plateaued and showed no progress towards maximum medical improvement, permanent and stationary status, and … Continue reading

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Reprogamming Cells Could Eliminate Dangers of Side Effects in Medicine

Posted: Published on June 8th, 2012

Human skin fibroblast cells under professional fluorescent microscope. Recent drugs that have been created can help treat some of the toughest diseases out therefrom Alzheimer's and Parkinson's to all types of cancers. The only problem: They kill some people. But new breakthroughs in cell engineering might usher in a new era of personalized medicine where drugs can be tested for side effects without having to test the drug in humans. Scientists at San Francisco's Gladstone Institutes announced Thursday that they've successfully reprogrammed human skin cells into brain cells, and recently, a team turned skin cells into working heart cells. [Single Bomb Blast Causes Soldiers NFL-like Brain Trauma] The idea, according to Yadong Huang, head of the Gladstone study, is to scrape cells from an Alzheimer's patient's skin, turn it into a brain cell, and try out different therapies on the newly-created cells. If there's an adverse reaction, doctors will know not to give that drug to the patient. "There are some drugs that can't be put on the market because some patients respond badly to a drug. If the drug kills 5 percent of the patients, the FDA won't approve it," Huang says. Instead of risking side effects, which range … Continue reading

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Vets First Choice Secures $4M in Growth Capital Led by Polaris Venture Partners

Posted: Published on June 8th, 2012

More Topics: Choose a Sector Accounting Firms Advertising/Media/Communications Capital CEO/Board General Business Health/Biotech Internet/Technology Investment Firms Law Firms Mergers & Acquisitions Money Managers People Private Companies Public Companies Venture Capital Posted June 6, 2012 PORTLAND, Maine--Vets First Choice, an online veterinary partner-pharmacy and marketing service provider, closed a $4 million financing led by new investor Polaris Venture Partners. Also participating were existing investors including Borealis Ventures, Harbor Light Capital, David Shaw and Black Point Group. Earlier this year Vets First Choice acquired VetCentric.com, creating the market leading veterinary partner-pharmacy provider licensed in 50 states and serving more than 6,000 veterinary practices. The new investment will support the company's continued growth and expansion in the veterinary services and home delivery space, a market estimated to exceed $5 billion in the United States. "Vets First Choice is a fantastic value proposition to veterinary practices and a trusted source for pet owners looking for high quality, convenient veterinary medicines," said Kevin Bitterman, Principal at Polaris Venture Partners. "The company's unique model supports the veterinary community's demand for a personalized approach to prescription fulfillment, high-quality care, and competitive pricing. We expect that Vets First Choice will continue to build on its impressive leadership position … Continue reading

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Pharmaceutical Strategies Group, LLC Announces New Suite of Services Aimed at Improving Specialty Pharmacy Management …

Posted: Published on June 8th, 2012

PLANO, TX--(Marketwire -06/07/12)- Today, Pharmaceutical Strategies Group, LLC ("PSG"), America's largest independent pharmacy benefits consulting and solutions firm, announced the immediate availability of a suite of Specialty Pharmacy Management Services featuring their RxDiagnostic for Specialty service, enabling large employers, health systems, managed care organizations and Taft-Hartley Funds/Unions to develop and implement a comprehensive specialty pharmacy management strategy to address their rapidly growing specialty drug spend. Plan sponsors are often resource-challenged and rely on specialty pharmacies or their medical and PBM vendors for information and guidance on specialty pharmacy management. The RxDiagnostic for Specialty and downstream solutions provide critical information and guidance as well as services not readily available in the marketplace, until now. Plan design, vendor performance, clinical management, reimbursement management, and site-of-care management are independently analyzed, reviewed, and benchmarked against best practices using sophisticated healthcare analytics. The unique feature of the diagnostic is the integrated performance analysis using both pharmacy and medical data. With 50% or more of the specialty drug spend falling into the medical benefit, utilizing proven data integration and analytics tools are critical to understanding performance and creating solutions. PSG utilizes their data integration/healthcare information analytics tool and clinical business intelligence engine, Artemetrx(SM), to support the … Continue reading

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Neil Riordan PhD – Stem Cell Therapy for Spinal Cord Injury (Part 3 of 5) || Stem Cell Treatments – Video

Posted: Published on June 8th, 2012

06-06-2012 13:09 Mesenchymal stem cell homing to tissue damage, umbilical cord stem cells historically used for anti-aging, mesenchymal stem cells role in immune system modulation, inflammation reduction and stimulating tissue regeneration, donor stem cell safety and testing, the role of HLA matching in donated umbilical cord-derived stem cells, umbilical cord blood safety data and historical use in blood transfusions, allogeneic stem cell persistence in human mothers. Treatment information at More information on Dr. Riordan at Read more: Neil Riordan PhD - Stem Cell Therapy for Spinal Cord Injury (Part 3 of 5) || Stem Cell Treatments - Video … Continue reading

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TiGenix: National Reimbursement in the Netherlands Obtained for Breakthrough Cartilage Therapy ChondroCelect(R)

Posted: Published on June 8th, 2012

LEUVEN, BELGIUM--(Marketwire -06/08/12)- TiGenix (EURONEXT:TIG) TiGenix obtains national reimbursement in the Netherlands for breakthrough cartilage therapy ChondroCelect TiGenix (EURONEXT:TIG) announced today that its innovative cartilage repair therapy ChondroCelect has obtained national reimbursement in the Netherlands. The Dutch National Health Authority (NZa) has formally announced that ChondroCelect is to receive national reimbursement retroactively per January 1, 2012. Previously ChondroCelect was made available in the Netherlands under a risk-sharing scheme. "We are delighted with the decision of the NZa to reimburse ChondroCelect, and look forward to working with Dutch orthopedic centers of excellence and health insurers to routinely make this breakthrough therapy available to the right patients in the Netherlands," said Eduardo Bravo, CEO of TiGenix. "Dutch clinicians and scientists have been instrumental in ChondroCelect's development and four Cartilage Expert Centers in the Netherlands have already gained extensive experience with the procedure. After having obtained national reimbursement in Belgium last year, this constitutes another major step in improving patient access to this innovative therapy. We remain optimistic that we can obtain national reimbursement in other European countries later this year." About TiGenix TiGenix NV (EURONEXT:TIG) is a leading European cell therapy company with a marketed product for cartilage repair, ChondroCelect, and a … Continue reading

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Skin Cells Turned Into Brain Cells

Posted: Published on June 8th, 2012

Brain cells of a laboratory mouse are shown glowing with multicolor fluorescent proteins. THURSDAY, June 7 (HealthDay News) -- Scientists who reprogrammed skin cells into brain cells say their research could lay the groundwork for new ways to treat Alzheimer's and other brain diseases. The team at the Gladstone Institutes in San Francisco transferred a gene called Sox2 into both mouse and human skin cells. Within days, the skin cells transformed into early-stage brain stem cells called induced neural stem cells. [Read: Scientists Turn Skin Cells Into Cardiac Cells to Help Failing Hearts.] These cells began to self-renew and soon matured into neurons capable of transmitting electrical signals. Within a month, these new neurons had developed into neural networks, according to the research published online June 7 in the journal Cell Stem Cell. These transformed cells could provide better models for testing new drugs to treat Alzheimer's and other brain diseases, the researchers said. "Many drug candidates -- especially those developed for neurodegenerative diseases -- fail in clinical trials because current models don't accurately predict the drug's effects on the human brain," Gladstone investigator Dr. Yadong Huang, who is also an associate professor of neurology at the University of California, … Continue reading

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