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New genetic factor associated with lean diabetics identified

Posted: Published on June 3rd, 2012

Washington, June 2 : Lean type 2 diabetes patients have a larger genetic disposition to the disease as compared to their obese counterparts, a new study has proved. Type 2 diabetes is popularly associated with obesity and a sedentary lifestyle. However, just as there are obese people without type 2 diabetes, there are lean people with the disease. It has long been hypothesised that type 2 diabetes in lean people is more "genetically driven". The study, from a research team led by the Peninsula College of Medicine and Dentistry (PCMD), University of Exeter, has also identified a new genetic factor associated only with lean diabetes sufferers. Using genetic data from genome-wide association studies, the research team tested genetic markers across the genome in approximately 5,000 lean patients with type 2 diabetes, 13,000 obese patients with the disease and 75,000 healthy controls. The team found differences in genetic enrichment between lean and obese cases, which support the hypothesis that lean diabetes sufferers have a greater genetic predisposition to the disease. This is in contrast to obese patients with type 2 diabetes, where factors other than type 2 diabetes genes are more likely to be responsible. In addition, genetic variants near the … Continue reading →

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The role of raisins in sexual health

Posted: Published on June 2nd, 2012

Including raisins in your everyday diet is a great way to ensure that your sexual health is on track! Raisins are packed with many essential nutrients that play an important role in keeping an individual sexually active and thriving. Raisins are rich in Vitamin A, selenium, potassium, iron and Vitamin B, and they also contain high levels of arginine and polyphenolic phytonutrients. In the following pages, we elaborate upon how each of these is important when it comes to sex. The role of Vitamin A in sexual health Studies have shown that Vitamin A deficiency can cause impotency. This is because it plays a very important role in progesterone synthesis -- and progesterone controls the entire menstrual cycle in women. Vitamin A also helps in keeping the inner lining of a woman's vagina and uterus healthy, without any damage. This nutrient plays a key role in maintaining epithelial tissues and women should include raisins in their diet for this very reason. In males, Vitamin A deficiency can cause atrophy in the testicles and decrease the overall production of sex hormones. LifeMojo is one of the most trusted sources of information about good health and wellness. To those who want to … Continue reading →

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Foundation Medicine Announces New Data Using Next-Generation Sequencing to Detect Cancer-Related Mutations Not …

Posted: Published on June 2nd, 2012

CAMBRIDGE, Mass. & CHICAGO--(BUSINESS WIRE)-- Foundation Medicine, Inc., a molecular information company that brings comprehensive cancer genomic analysis to routine clinical care, today announced results from two studies using next-generation sequencing (NGS) to provide actionable information about genomic tumor alterations in individual patients cancers across all solid tumor types. The studies, being presented this week in an oral and poster session at the 2012 Annual Meeting of the American Society of Clinical Oncology (ASCO), provide new evidence of the important role and clinical impact of NGS in cancer treatment. These data follow Foundation Medicines recent launch of FoundationOne, the first pan-cancer, fully informative genomic profile for all solid tumors. These studies, along with other results previously presented and published, provide unequivocal evidence of the significant clinical value of NGS-based comprehensive genomic analysis, said Michael J. Pellini, president and chief executive officer, Foundation Medicine. One test, using a very small amount of tissue, can enable physicians to tailor treatment to a patients molecular subtype. With our pan-cancer genomic profile now commercially available, physicians will have a critical decision-making tool to assist them in making the most appropriate therapeutic choices for their patients with cancer. The first study, Discovery of Recurrent KIF5B-RET … Continue reading →

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Stem cell therapy for cornea treatment

Posted: Published on June 2nd, 2012

Hyderabad, June 2: Picking stem cells from a patients body, sending it to a sophisticated laboratory to culture a tissue and then implanting it are pass. A team of doctors at L.V. Prasad Eye Institute has used the tea bag or sprinkler approach to regenerate stem cells. The organisation has developed a lab-free technique that could be available off-the-shelf. This allows eye surgeons with usual facilities to perform the procedure. The team, led by Dr Virender Singh Sangwan, used this technique to treat those who suffered chemical injuries, resulting in bleeding in the cornea. Instead of sending stem cells to the lab for culture, the doctor picked the required number of stem cells around the cornea and sprinkled on the damaged area and then put a contact lens. In 15 days, he sees development of a good layer in the place of injured area, Prof. Balasubramanian, Head of Research at LVPEI, said. A winner of the prestigious Shanti Swarup Bhatnagar prize, Dr Sangwan said he had conducted the procedure on about 25 patients with good results. This had been published in international scientific magazines. He is now in the process of developing tools to help doctors. Leber Congenital Amaurosis Children … Continue reading →

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UPDATE 1-J&J hormone-blocking pill slows prostate cancer spread

Posted: Published on June 2nd, 2012

* Estimated to improve survival by 33 pct * Side effects include cardiac disorder, high blood pressure * Zytiga U.S. sales could reach $1.5 bln annually - analyst (Recasts, adds analyst comment, Medivation (NasdaqGM: MDVN - news) trial details) CHICAGO, June 2 (Reuters) - A trial of Johnson & Johnson (TLO: JNJ-U.TI - news) 's Zytiga in certain prostate cancer patients showed that it doubled the amount of time they lived without the disease getting worse, potentially offering new hope for patients who see their cancer return. The trial, involving 1,088 patients who had stopped responding to traditional hormonal drugs but had not been treated with chemotherapy, found that Zytiga slowed the spread of the disease by 58 percent. Zytiga is one of several new prostate cancer treatments that may significantly prolong the life of patients by zeroing in more closely on certain mechanisms that help tumors proliferate. New data on the medications are being presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago. The drug's robust results in earlier-stage cancer - it is already approved for men with prostate cancer who previously received chemotherapy - have implications for companies like Dendreon (Xetra: 615606 - news) … Continue reading →

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Breakthrough breast cancer drug can extend life of sufferers who have one of disease's most deadly forms

Posted: Published on June 2nd, 2012

By Nick Craven PUBLISHED: 17:21 EST, 2 June 2012 | UPDATED: 17:22 EST, 2 June 2012 A new magic bullet drug to be unveiled today will offer hope for thousands of women suffering one of the most deadly forms of breast cancer. The medicine, aimed at an aggressive form of the disease, is expected to offer several months of quality extra life and drastically cuts the debilitating side effects of traditional therapy. It could be available in Britain within a year, provided it passes regulatory checks. But experts predict that a clamour for the drug, codenamed T-DM1, will put added financial pressure on the NHS. Dr Eliot Sims of King George Hospital, Ilford, in Essex, who was part of a trial of the drug, said: Is the emergence of T-DM1 going to cause funding problems? You bet it will. Breakthrough: The medicine is expected to offer several months of quality extra life for breast cancer sufferers The clinical consultant oncologist added: Its been the holy grail of oncology to find magic bullets treatments which attack breast cancer without causing side effects. This is a huge breakthrough, and it is unusual to see such dramatic improvements. Pharmaceutical giant Roche is due … Continue reading →

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Drugs may prompt immune system to strike cancer

Posted: Published on June 2nd, 2012

CHICAGO Medical science efforts to harness the power of the immune system against cancer are beginning to bear fruit after decades of frustration, opening up a hopeful new front in the long battle against the disease. In studies being presented Saturday, researchers said two experimental drugs by Bristol-Myers Squibb Co. significantly shrank tumors in some patients with advanced skin, lung and kidney cancers. Especially promising was that the drugs worked against several types of cancer, researchers said of the early findings. Most of the patients whose tumors responded significantly to the treatment saw long-term results. The new drugs empower the immune system to recognize cancer cells as an enemy and attack them, although the treatments can have serious side effects. The immune system's ability to fight off the body's invaders has long been recognized against infectious disease. But cancer has largely escaped its reach and for decades fended off researchers' efforts to find a weakness. It turns out cancer shields itself by essentially putting the brakes on the human immune system. Recent discoveries have led to advances in how to unleash the immune system, though one challenge has been to jump-start the body's defenses without injury to healthy, normal cells. … Continue reading →

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Seattle Genetics Announces ADCETRIS® Clinical Data to be Reported in Multiple Presentations at ASCO Annual Meeting

Posted: Published on June 2nd, 2012

CHICAGO--(BUSINESS WIRE)-- Seattle Genetics, Inc. (SGEN) today announced that data from several clinical trials of ADCETRIS (brentuximab vedotin) will be presented at the 2012 American Society of Clinical Oncology (ASCO) Annual Meeting being held June 1-5, 2012 in Chicago, IL. Data demonstrate the activity and tolerability when patients are retreated with ADCETRIS, the activity and tolerability of ADCETRIS in CD30-positive non-Hodgkin lymphomas and CD30 expression from a screening protocol in non-lymphoma malignancies. ADCETRIS is an antibody-drug conjugate (ADC) directed to CD30. Our goal is for ADCETRIS to become the foundation of therapy for CD30-positive malignancies and, to that end, we are aggressively investing in its clinical development and broadly exploring CD30 expression across numerous cancer types, said Clay B. Siegall, Ph.D., President and Chief Executive Officer of Seattle Genetics. Our data presentations at ASCO highlight the potential for ADCETRIS and reinforce our development strategy to generate data that will support stepwise growth of ADCETRIS for patients with CD30-expressing malignancies. Retreatment with brentuximab vedotin in CD30-positive hematologic malignancies: a phase II study (Abstract #8027) In a phase II trial, patients who previously responded to treatment with ADCETRIS, then discontinued treatment and subsequently had disease progression or relapse were eligible for retreatment. … Continue reading →

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Stem cell therapy for cornea treatment

Posted: Published on June 2nd, 2012

Hyderabad, June 2: Picking stem cells from a patients body, sending it to a sophisticated laboratory to culture a tissue and then implanting it are pass. A team of doctors at L.V. Prasad Eye Institute has used the tea bag or sprinkler approach to regenerate stem cells. The organisation has developed a lab-free technique that could be available off-the-shelf. This allows eye surgeons with usual facilities to perform the procedure. The team, led by Dr Virender Singh Sangwan, used this technique to treat those who suffered chemical injuries, resulting in bleeding in the cornea. Instead of sending stem cells to the lab for culture, the doctor picked the required number of stem cells around the cornea and sprinkled on the damaged area and then put a contact lens. In 15 days, he sees development of a good layer in the place of injured area, Prof. Balasubramanian, Head of Research at LVPEI, said. A winner of the prestigious Shanti Swarup Bhatnagar prize, Dr Sangwan said he had conducted the procedure on about 25 patients with good results. This had been published in international scientific magazines. He is now in the process of developing tools to help doctors. Leber Congenital Amaurosis Children … Continue reading →

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Paralysed patients may get revolutionary treatment after rats with severed spinal cords taught to sprint again after …

Posted: Published on June 2nd, 2012

By Tamara Cohen PUBLISHED: 13:14 EST, 31 May 2012 | UPDATED: 06:18 EST, 1 June 2012 Paralysed patients have been given fresh hope after scientists enabled rats with severed spines to run again. Using a cocktail of drugs and electrical impulses, researchers regrew nerves linking the spinal cord to the brain. After two weeks, the animals were not only able to walk, but climb stairs and run. Scroll down for video: Climbing the steps: Researchers at EPFL have successfully used electrochemical stimulation to restore voluntary movement following a paralysing spinal cord injury After only a few weeks of stimulation, nerve connections begin to grow again - and this could be of huge significance for the 50,000 sufferers Professor Gregoire Courtine said the study revealed the body could recover from some injuries previously thought to cause permanent paralysis. His team, based in Switzerland, believe human trials could begin next year for patients with spinal injuries thanks to a 7million grant. Continued here: Paralysed patients may get revolutionary treatment after rats with severed spinal cords taught to sprint again after ... … Continue reading →

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