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Stem cell therapy for 13-year-old dog helps with its arthritis

Posted: Published on March 28th, 2012

COLUMBIA, SC (WIS) - A few weeks ago, we told you the story of Maggie, the 13-year-old Boykin Spaniel who was suffering from arthritis. Maggie is enjoying life once again thanks to a new type of surgery. The dog received stem cell therapy surgery six weeks ago. Doctors were able to use adult stem cells from Maggie's blood and fat samples to collect repair cells. They then took the cells and repaired the dog's arthritic spine. Maggie's owner, Beth Phibbs, says she could tell the dog had been in pain. "You could tell she didn't feel well, but yet now she is like she's 5 and she's 13. She just runs out and she plays. I think she knows. She can feel the difference," Phibbs said. The surgery costs about $2,000, but Medi-vet America says this costs about half as much as the older treatments. Previous Story: Copyright 2012 WIS. All rights reserved. The rest is here: Stem cell therapy for 13-year-old dog helps with its arthritis … Continue reading

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Cell Therapy Improves Damaged Heart In Study

Posted: Published on March 28th, 2012

March 27, 2012 According to a new study, using a patients own bone marrow may help repair damaged areas of the heart caused by heart failure. Researchers found that left ventricular ejection fraction increased by 2.7 percent in patients who received stem cell therapy. The study, which was presented at the American College of Cardiologys 61st Annual Scientific Session, revealed that the improvement in ejection fraction correlated with the number of CD34+ and CD133+ cells in the bone marrow. This is the kind of information we need in order to move forward with the clinical use of stem cell therapy, Emerson Perin, MD, PhD, director of clinical research for cardiovascular medicine at the Texas Heart Institute and the studys lead investigator, said at the event. The study included 92 patients who were randomly selected to receive stem cell treatment or placebo. The patients all had chronic ischemic heart disease and an ejection fraction of less than 45 percent along with heart failure. Doctors placed a catheter in the hearts left ventricle to inject 3 ccs, or 100 million stem cells, into an average of 15 sites of the stem cell patients hearts. The doctors used electromechanical mapping of the heart … Continue reading

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Legislature targets drugs in 'bath salts' as formulas change

Posted: Published on March 28th, 2012

by Alex Ferri - Mar. 27, 2012 09:27 PM The Republic | azcentral.com Despite a new state law that bans certain ingredients used to make a synthetic drug known as "bath salts," manufacturers found a way to tweak their formulas to keep the drug on store shelves. So, legislators are at it again -- this time trying to find a longer-term solution to banning such drugs. The Senate Rules Committee will vote again on House Bill 2388, which would allow the Arizona State Board of Pharmacy to ban the chemicals used in bath salts. The bill failed in the committee Monday over concerns about its constitutionality, but Sen. Linda Gray, R-Phoenix, said at a Tuesday news conference that she expects the bill to pass on its second vote. Gov. Jan Brewer in February signed into law a bill banning seven primary chemicals in bath-salt drugs. But drug manufacturers began to use modified versions of the old chemicals that aren't specifically prohibited by the law, Gray said, a loophole that HB 2388 aims to eliminate. Gray said the Legislature can't always keep up with banning every new substance drug manufacturers use in bath salts because the Legislature isn't always in session … Continue reading

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Death, Drugs, 'Salvation And Soccer' In Juarez

Posted: Published on March 28th, 2012

Of course you know that Ciudad Juarez is a terrifying murder hole, a blood-soaked entry point for drugs into the U.S. from Mexico. It is hell on earth, isn't it? Rival cartels fighting for control of the region kill with impunity and without discretion. Cops? They're hit men. The Federales? Ineffectual at best, complicit at worst. And let us not forget the wave of femicide that's swept through Juarez over the past 15 or so years, leaving thousands of women missing or murdered and dumped wherever was convenient for the men who would never be arrested or charged for their crimes. It's not the kind of place where anyone with half a lick of sense would want to end up. Which is why it's a bit baffling that a hapless sportswriter named Robert Andrew Powell would wash up there a couple years ago, broke, and decide to stay. But, then again, it's cheap, and once Powell gets past the idea that he could be gunned down at any moment, it's really not that bad of a place. With nice people and good food and an astronomically high crime rate and no functioning justice system and one hell of a terrible … Continue reading

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Stem cell segment in India to touch $8 billion mark by 2015: Report

Posted: Published on March 28th, 2012

HYDERABAD: Lack of legislation and awareness coupled with quality and ethical Issues has been deterrent to the growth of stem cell therapy sector in India, where the bio-tech market is expected to achieve a market size of $ 8 billion by 2015, according to a report by the Yes bank. Special provisions such as 10-year tax benefits, duty exemptions, fast tracking the approval process by giving it a status of orphan drug (as done in the US) are some measures which could be very helpful to become leaders in this sector, the report 'Stem Cells--an emerging Bio-sector' suggested. "The legislation for this sector still is at the draft stage. A regulatory framework governing the sector, instead of the guidelines existing at present is essential for the proper growth of stem cell research and applications in India. There are also no guidelines regarding pricing which results in certain unproven injections being sold for around Rs 80,000," the report said. Several companies are taking advantage of the lack of laws governing the stem cell segment and advertise their therapies and clinical trials as ICMR approved. However, given the multi-tiered system of registration and approvals recommended in the ICMR's guidelines, some of these … Continue reading

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Gentium Reports Fourth Quarter and Year End 2011 Financial Results

Posted: Published on March 28th, 2012

Defibrotide usage increased by 28% to EUR 16.89 million (US$ 21.91 million) Total product sales of EUR 21.73 million (US$ 28.19 million) Net income of EUR 2.71 million (US$ 3.52 million) Cash flow positive and stronger cash position VILLA GUARDIA (COMO), Italy, March 27, 2012 (GLOBE NEWSWIRE) -- Gentium S.p.A. (Nasdaq:GENT - News) (the "Company") today reported financial results for the quarter and year ended December 31, 2011. The Company reports its financial and operating results using U.S. Generally Accepted Accounting Principles (GAAP). The Company's financial statements are prepared using the Euro as its functional currency. On December 31, 2011, EUR 1.00 = $1.2973. "We are pleased to report that Defibrotide usage increased by 28% in 2011 when compared with 2010, and total product sales fell within our most recent range of guidance of EURO21-23 million ($27.2 -$29.8 million). We have been able to finance the establishment of our European commercial team, repay the current portion of our long-term debt and fund our working capital," stated Salvatore Calabrese, SVP Finance and Chief Financial Officer of Gentium S.p.A. "We ended 2011 with a net income of EURO2.71 million ($3.52 million), which was impacted by a tax reform that established a minimum … Continue reading

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ImmunoCellular Therapeutics to Present on Cancer Stem Cell Targeting at the AACR Annual Meeting

Posted: Published on March 28th, 2012

ImmunoCellular Therapeutics, Ltd. (ImmunoCellular or the Company) (OTCBB: IMUC), a biotechnology company focused on the development of novel immune-based cancer therapies, announced today that the Company will deliver a presentation on the identification and characterization of immunogenic epitopes from CD133 and their potential for use to immunologically target cancer stem cells (CSCs) at the Annual Meeting of the American Association for Cancer Research, which will be held from March 31 to April 4, 2012 at McCormick Place in Chicago, Illinois. CD133 is a marker that identifies CSCs on many solid tumors and its expression has been correlated with shortened survival. Potential Cytotoxic T Lymphocytes (CTL) epitopes were identified by computer algorithms to predict binding to HLA-A2 tissue type on white blood cells. Studies with human cells in vitro demonstrated immunogenicity of two lead peptides and in vivo studies in mice confirmed the safety and immunogenicity of these peptides as a potential vaccine to target CD133 CSCs. The Company plans to incorporate these peptides into its second product, ICT-121, for recurrent glioblastoma as the initial indication, followed by additional solid tumors. To evaluate the potential for autoimmunity, mouse homolog peptides of the lead epitopes that were shown to have high affinity … Continue reading

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Vatican stem cell conference cancelled partly over keynote speaker George Daley from Boston

Posted: Published on March 28th, 2012

By Carolyn Y. Johnson, Globe Staff An international stem cell conference scheduled to take place next month at the Vatican has been cancelled, and the Catholic News Agency has reported that the choice of speakers, which included a prominent Boston embryonic stem cell researcher, was a factor. Dr. George Q. Daley, a stem cell researcher at Childrens Hospital Boston, was scheduled to give the opening lecture at the Third International Congress on Responsible Stem Cell Research. Daley said in an interview that he received a brief e-mail late last week announcing that the conference had been cancelled and that an explanation would follow shortly. Unnamed sources told the Catholic News Agency that the event, as planned, would have presented an unacceptably ambivalent stance on embryonic stem cell research. The Catholic Church opposes human embyronic stem cell research because it requires the destruction of embryos. One unnamed member of the Pontifical Academy for Life told the news agency: The news of the cancellation of the Congress is an enormous relief to many members of the Pontifical Academy for Life, who felt that the presence on its program of so many speakers, including the keynote speaker, committed to embryonic stem cell research, … Continue reading

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Cell Therapy Improves Damaged Heart In Study

Posted: Published on March 28th, 2012

March 27, 2012 According to a new study, using a patients own bone marrow may help repair damaged areas of the heart caused by heart failure. Researchers found that left ventricular ejection fraction increased by 2.7 percent in patients who received stem cell therapy. The study, which was presented at the American College of Cardiologys 61st Annual Scientific Session, revealed that the improvement in ejection fraction correlated with the number of CD34+ and CD133+ cells in the bone marrow. This is the kind of information we need in order to move forward with the clinical use of stem cell therapy, Emerson Perin, MD, PhD, director of clinical research for cardiovascular medicine at the Texas Heart Institute and the studys lead investigator, said at the event. The study included 92 patients who were randomly selected to receive stem cell treatment or placebo. The patients all had chronic ischemic heart disease and an ejection fraction of less than 45 percent along with heart failure. Doctors placed a catheter in the hearts left ventricle to inject 3 ccs, or 100 million stem cells, into an average of 15 sites of the stem cell patients hearts. The doctors used electromechanical mapping of the heart … Continue reading

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Stem cell study aids quest for motor neuron disease therapies

Posted: Published on March 28th, 2012

ScienceDaily (Mar. 26, 2012) A breakthrough using cutting-edge stem cell research could speed up the discovery of new treatments for motor neuron disease (MND). The international research team has created motor neurons using skin cells from a patient with an inherited form of MND. Role of protein Using patient stem cells to model MND in a dish offers untold possibilities for how we study the cause of this terrible disease as well as accelerating drug discovery by providing a cost-effective way to test many thousands of potential treatments said Professor Siddharthan Chandran, Director of the University's Euan MacDonald Centre for MND Research. The study discovered that abnormalities of a protein called TDP-43, implicated in more than 90 per cent of cases of MND, resulted in the death of motor neuron cells. This is the first time that scientists have been able to see the direct effect of abnormal TDP-43 on human motor neurons. The study, led by the University of Edinburgh's Euan MacDonald Centre for Motor Neuron Disease Research, was carried out in partnership with King's College London, Columbia University, New York and the University of San Francisco. Motor neuron disease MND is a devastating, untreatable and ultimately fatal condition … Continue reading

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