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New epilepsy gene located in dogs

Posted: Published on March 24th, 2012

ScienceDaily (Mar. 23, 2012) A new epilepsy gene for idiopathic epilepsy in Belgian Shepherds has been found in the canine chromosome 37. The research of Professor Hannes Lohi and his group conducted at the University of Helsinki and the Folkhlsan Research Center opens new avenues for the understanding of the genetic background of the most common canine epilepsies. The research also has an impact on the understanding of common epilepsies in humans. The research is published in the scientific journal PLoS ONE on March 23, 2012. Epilepsy affects about 1-5% of the human population at some stage of live, and it includes a host of syndromes the age of onset, causes and prognosis of which vary significantly. Based on their basic mechanisms epilepsy syndromes are divided into genetic (idiopathic) epilepsies, structural / metabolic (symptomatic) epilepsies and epilepsies of unknown cause. Symptomatic causes refer to discernible external or structural change, whereas with idiopathic epilepsy there is a strong genetic background. A common denominator between the different syndromes are reoccurring epileptic seizures, which are divided according to an international classification into two main groups -- focal and generalized seizures -- based on clinical symptoms and research findings. About two thirds of the … Continue reading

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Fashion Bug Partners With Autism Speaks to Launch "Spare Change Makes a Difference" Campaign

Posted: Published on March 24th, 2012

BENSALEM, Pa., March 23, 2012 /PRNewswire/ --Leading women's specialty retailer, Fashion Bug, is proud to announce the launch of its partnership with Autism Speaks, the world's leading autism science and advocacy organization. Beginning March 25, 2012, Fashion Bug invites consumers to "round up at the register" and join in their effort to raise money for Autism Speaks' core mission of research, prevention, treatments and a cure for autism. This community awareness and fundraising campaign will take place from March 25 through April 7, 2012 at all Fashion Bug stores across the country. During this time, customers are encouraged to "round up" purchases to the next whole dollar amount and Fashion Bug will donate the spare change to Autism Speaks for support of the charity's programs. "Autism is the fastest-growing serious developmental disability in the U.S., affecting an estimated 1.5 million people. We wanted to join forces with the organization leading the charge in research and advocacy for this pervasive disorder," said MaryEllen MacDowell, President of Fashion Bug, about the partnership. "Our customers are very compassionate and together we know we can make a significant contribution to Autism Speaks through the 'Spare Change Makes a Difference' campaign." Fashion Bug will also … Continue reading

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Stroke Progress Review Group sets priorities for future NIH stroke rehabilitation research

Posted: Published on March 24th, 2012

Public release date: 23-Mar-2012 [ | E-mail | Share ] Contact: Carolann Murphy CMurphy@KesslerFoundation.org 973-324-38382 Kessler Foundation West Orange, NJ. March 23, 2012. In 2011, the National Institute of Neurological Disorders and Stroke (NINDS) convened the Stroke Progress Review Group (SPRG) to conduct a final 10-year review of the state of stroke research. The goal is to set priorities and shape future NINDS programs and policies. While SPRG found much available data for maximizing stroke rehabilitation outcomes, translation to clinical practice is inadequate. To realize the enormous potential for improving rehabilitation and recovery, more resources should be applied to implementing and directly supporting SPRG's recommendations. The Final Report of the Stroke PRG is on the NINDS SPRG website: http://www.ninds.nih.gov/find_people/groups/stroke_prg/01-2012-stroke-prg-report.htm. The working group for rehabilitation and recovery was co-chaired by Anna Barrett, MD, director of Stroke Rehabilitation Research at Kessler Foundation, Pamela Duncan, PT, PhD, Duke Center for Clinical Health Policy Research, with Steven C. Cramer, MD (NINDS liaison co-chair). "The strategic plan and vision set out in the 2002 SPRG was intended for ten-year implementation," said Dr. Barrett. "To assess progress in rehabilitation and recovery, we recruited eleven working group members (John Chae, Leonardo Cohen, Bruce Crosson, Leigh Hochberg, Rebecca … Continue reading

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Proteome Sciences Contributing Protein Biomarker Analysis to New $14.6M EU Stroke Initiative

Posted: Published on March 24th, 2012

By Adam Bonislawski Proteome Sciences said this week that it will be performing biomarker analysis for a new European research initiative to study hypothermia as a treatment after stroke. The research project, called EuroHyp-1, is a phase III clinical trial investigating the effectiveness of cooling the brain within six hours of a stroke. The 1,500-patient trial, which involves 60 universities and hospitals in 25 countries, is being funded by an 11 million ($14.6 million) grant from the European Commission under the Seventh Framework Programme. As part of the project, UK-based Proteome Sciences will use its mass spectrometry-based assays to perform biomarker analysis of patient samples in blood, the company said. According to Ian Pike, Proteome Sciences' chief operational officer, the biomarkers the company plans to analyze stem from a separate stroke research collaboration between Proteome Sciences and the lab of University of Geneva researcher Jean-Charles Sanchez. That work, Pike told ProteoMonitor, has focused on identifying protein markers in plasma that can rapidly distinguish between ischemic and hemorrhagic stroke, which is key to determining whether patients can be given tissue plasminogen activator, or t-PA, treatment, a therapy that dissolves blood clots and is therefore effective against ischemic, or blocked, strokes, but … Continue reading

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Using Tai Chi to Battle Parkinson's

Posted: Published on March 24th, 2012

The ancient Chinese exercise is low impact, not very difficult to learn, and does not require any special equipment. It also improved balance and posture, two problems many with PD face. zhu difeng/Shutterstock Parkinson's Disease (PD) is a progressive motor system disorder characterized by tremor; rigidity or stiffness of arms, legs, and trunk; slowness of movements; and poor balance and coordination. Patients with Parkinson's may experience diminished ability to perform their daily activities and have an increased risk of falling. This eventually leads to significant impairment in their quality of life. While medications can be helpful, there is no cure and medications are less effective in treating the postural and balance problems associated with PD. Tai chi is an ancient Chinese exercise involving gentle, flowing movements and postures. It has health benefits that include reducing stress and improving balance and posture. It is low impact, not difficult to learn, and does not require any equipment. Both physical exercise and tai chi have been shown to improve strength, balance, and general functioning in seniors and to slow the loss of muscular functions. Researchers recently looked at the effect of tai chi on balance, gait, and daily function in patients with mild … Continue reading

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Hundreds farewell Jaye Radisich

Posted: Published on March 24th, 2012

Former State Labor MP Jaye Radisich was given a standing ovation as she was farewelled by hundreds of mourners at Fremantle Cemetery today. Ms Radisich died last Saturday aged 35 after battling a rare kidney cancer. Among the mourners were Defence Minister Stephen Smith, State Opposition Leader Mark McGowan, former State Labor leader Eric Ripper, former State Labor MP and Vincent mayor Alannah MacTiernan, retiring Labor MP John Kobelke, former Labor and now National Party MP Vince Catania, Deputy Opposition Leader Roger Cook and Liberal MP Robyn McSweeney. Ms Radisich was remembered by friends and family as the life of the party, passionate, enthusiastic and honest. The lively former politician rose to fame when at 23 years of age she became the youngest woman ever elected to WAs Parliament. Opposition police spokeswoman Michelle Roberts spoke about Ms Radisichs remarkable victory in Swan Hills at the 2001 election when she managed an 11.7 per cent swing to win the seat for Labor. Ms Roberts said Ms Radisich had kept a promise made in her maiden speech to Parliament to keep it real and had livened up the stuffy corridors of Parliament. Ms Radisichs friend Daniel Smith delivered the eulogy saying he … Continue reading

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Dr. Rebecca Carley : Vaccines

Posted: Published on March 24th, 2012

22-03-2012 12:29 Dr. Rebecca Carley talks about the vast dangers of vaccines and other AMA-approved treatments that actually do greater harm. website: drcarley.com (expand for more info) "The only safe vaccine is one that is never used." (Dr.James R. Shannon, former Director National Institute of Health) Vaccine Ingredients - Formaldehyde, Aspartame, Mercury + more The numbers of microbes, antibiotics, chemicals, heavy metals and animal byproducts is staggering. Would you knowingly inject these materials into your children? This following list of common vaccines and their ingredients should shock anyone --- eye-opening list here http://www.rense.com (page xcerpt) Acel-Immune DTaP - Diphtheria-Tetanus-Pertussis Wyeth-Ayerst 800.934.5556 * diphtheria and tetanus toxoids and acellular pertussis adsorbed, formaldehyde, aluminum hydroxide, aluminum phosphate, thimerosal, and polysorbate 80 (Tween-80) gelatin Act HIB Haemophilus - Influenza B Connaught Laboratories 800.822.2463 * Haemophilus influenza Type B, polyribosylribitol phosphate ammonium sulfate, formalin, and sucrose Attenuvax - Measles Merck & Co., Inc. 800-672-6372 * measles live virus neomycin sorbitol hydrolized gelatin, chick embryo Biavax - Rubella Merck & Co., Inc. 800-672-6372 * rubella live virus neomycin sorbitol hydrolized gelatin, human diploid cells from aborted fetal tissue BioThrax - Anthrax Adsorbed BioPort Corporation 517.327.1500 * nonencapsulated strain of Bacillus anthracis aluminum hydroxide, benzethonium chloride, … Continue reading

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Study identifies genetic variants linked to fatty liver disease in obese children

Posted: Published on March 24th, 2012

Public release date: 23-Mar-2012 [ | E-mail | Share ] Contact: Dawn Peters healthnews@wiley.com 781-388-8408 Wiley-Blackwell New research found the genetic variant Patatin-like phospholipase domain containing protein-3 (PNPLA3) acting in conjunction with the glucokinase regulatory protein (GCKR) is associated with increased susceptibility to fatty liver disease in obese children. The study, published in the March issue of Hepatology, a journal of the American Association for the Study of Liver Diseases, determined the PNPLA3 and GCKR single nucleotide polymorphisms (SNPs) were responsible for up to 39% of the hepatic fat content in this pediatric population. Obesity is a global health concern and children are not unscathed by this epidemic. As a result, experts say nonalcoholic fatty liver disease (NAFLD) is now the leading cause of chronic liver disease in children and adolescents in industrialized countries. Previous studies indicate genetics significantly impacts the susceptibility of developing fatty liver and nonalcoholic steatohepatitis (NASH), particularly in early-onset disease, which places greater interest on childhood obesity. For the current study, a team led by Dr. Nicola Santoro from Yale University School of Medicine in New Haven, Connecticut recruited 455 obese children and adolescents who underwent genotyping and fasting triglycerides and lipoprotein particles testing. Participants in … Continue reading

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Nobel Laureate Peter Agre, MD, to Speak at the Perelman School of Medicine Commencement

Posted: Published on March 24th, 2012

PHILADELPHIA Nobel Laureate Peter Agre, MD, professor and director of the Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health, will deliver the address at the Perelman School of Medicine's commencement ceremony on Sunday, May 13, 2012 in Verizon Hall at the Kimmel Center for the Performing Arts. Dr. Agre's research in red-blood-cell biochemistry led to the first known membrane defects in congenital hemolytic anemias (spherocytosis) and produced the first isolation of the Rh blood group antigens. In 1992, his laboratory became widely recognized for discovering the aquaporins, a family of water channel proteins found throughout nature and responsible for numerous physiological processes in humans including kidney concentration, as well as secretion of spinal fluid, aqueous humor, tears, sweat, and release of glycerol from fat. Aquaporins have been implicated in multiple clinical disordersincluding fluid retention, bedwetting, brain edema, cataracts, heat prostration, and obesity. Water transport in lower organisms, microbes, and plants also depend upon aquaporins. For this work, Dr. Agre shared the 2003 Nobel Prize in Chemistry with Roderick MacKinnon of Rockefeller University. Dr. Agre received his medical degree from the Johns Hopkins School of Medicine in 1974. In 1981, after post-graduate medical training and a fellowship at the … Continue reading

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Potential Combination Therapy For Esophageal Cancer

Posted: Published on March 24th, 2012

Editor's Choice Academic Journal Main Category: Ear, Nose and Throat Also Included In: Cancer / Oncology Article Date: 23 Mar 2012 - 8:00 PDT email to a friend printer friendly opinions Current Article Ratings: In the March 20 issue of the journal Cancer Cell, researchers at The University of Texas MD Anderson Cancer Center reveal that the mTOR molecular pathway stimulates the activity of the Gli1 protein in the development and progression of esophageal cancer. Senior author of the study, Mien-Chie Hung, Ph.D., vice president for basic research, professor and chair of MD Anderson's Department of Molecular and Cellular Oncology, explained: Crosstalk between these two pathways is a challenge, but our experiments showed a combination of the mTOR inhibitor RAD-001 (Afinitor) and the Hedgehog inhibitor GDC-0449 (Erivedge) steeply reduced the tumor burden in a mouse model of esophageal adenocarcinoma." The U.S. Food and Drug Administration (FDA) has approved both drugs for use in other types of cancer. After examining 107 tissue samples of human esophageal cancer, the researchers found that 87 (81.3%) had a marker of Gli1 activated by Hedgehog and 80 (74.8%) had a marker of mTOR promotion of Gli1. According to the researchers less than 20% of individuals … Continue reading

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