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Claremont Salon to Kick Off Autism Awareness Month in April With 'Spa Day' Autism Fundraiser 3/31

Posted: Published on March 22nd, 2012

CLAREMONT, CA--(Marketwire -03/21/12)- Autism supporters can get pampered for a good cause during Cielo Mio Spa & Salon's "Spa Day for Autism Speaks" fundraiser in Claremont on Saturday, March 31, 2012, in observance of World Autism Awareness Day April 2 and Autism Awareness Month in April. Cielo Mio Spa & Salon will offer: Cielo Mio Spa & Salon raised and donated $1238 to Autism Speaks in 2011, and over $700 in 2010. "We are proud to offer a relaxing way to raise funds for Autism Speaks and this very worthwhile cause," says Thomas Vuq, owner of Cielo Mio Spa & Salon. For more information on the fundraiser, visit https://www.facebook.com/pages/Cielo-Mio-Spa-Day-for-Autism-Speaks/203909856285823 Cielo Mio Spa & Salon is located at 101 North Indian Hill Blvd #c2-200 in Claremont. For questions or to make a reservation, contact (909) 621-5140 or email@cielomiospa.com. Additionally, Cielo Mio Spa and Salon will be the featured spa during the 10th Anniversary Los Angeles Walk Now for Autism Speaks to be held at the Pasadena Rose Bowl on April 21, 2012. The spa will donate massage services from 8 to 10:30 a.m. in the Walk's Grand Club, for walkers who raise $1,000 or more. ABOUT CIELO MIO SPA & SALON: … Continue reading

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Build-A-Bear Workshop Continues Support for Autism Speaks in Honor of Autism Awareness Month

Posted: Published on March 22nd, 2012

ST. LOUIS--(BUSINESS WIRE)-- Build-A-Bear Workshop, the interactive retailer of customized stuffed animals, announced today that it will raise funds for Autism Speaks with the help of Guests throughout the month of April. This is the eighth consecutive year that Build-A-Bear Workshop has supported the charity, which funds research into the causes, prevention and treatments for autism and advocates for the needs of individuals with autism and their families. Guests can support Autism Speaks by donating $1 (or more) when they check out at Build-A-Bear Workshop stores in the United States or online at buildabear.com. In Canada, Guests may purchase purple satin hearts for $1 throughout the month of April to support Autism Speaks. Guests can also give back at Bearville.com, the companys virtual world and entertainment destination and from April 1 through June 30th, by a percentage of the purchase price of Bearville Outfitters Virtual Stuff Game Cards to Autism Speaks when they activate their cards. Since 2004, Build-A-Bear Workshop has raised more than $545,000 to support Autism Speaks. Build-A-Bear Workshop is dedicated to supporting causes that matter most to our Guests, including autism spectrum disorders that affect children and their families, said Maxine Clark, Build-A-Bear Workshop founder and chief … Continue reading

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More stroke patients getting clot-busting drugs

Posted: Published on March 22nd, 2012

New figures collated by the Royal College of Physicians show eight per cent of stroke patients now receive the treatment, called thrombolysis. Experts say some 20 per cent of patients are clinically suitable for the drugs, which have to be administered within about four-and-a-half hours of a stroke to be effective. The rise follows a push, as a result of the 2007 National Stroke Strategy, to increase use of clot-busting drugs. Studies show thrombolysis can reduce the chance of death and serious disablity in stroke. An estimated 150,000 people have a stroke in Britain every year, while they account for about 53,000 deaths. The audit suggests that most stroke patients who do not receive thrombolysis are failing to do so because they do not get to a hospital's stroke unit in time. Just over half (53 per cent) are admitted to a stroke unit with four hours. A third are first admitted to other parts of a hospital before being referred to the stroke unit, which often means they get there too late for clot-busting drugs treatment. The RCP also expressed concerns that poorer performing hospitals may be refusing to submit information - leading to an overly-rosy picture. Professor Tony … Continue reading

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Stroke patients admitted to hospital 'out of hours' wait twice as long to be assessed

Posted: Published on March 22nd, 2012

By Daily Mail Reporter PUBLISHED: 19:04 EST, 20 March 2012 | UPDATED: 19:04 EST, 20 March 2012 About 150,000 Britons have a stroke each year Stroke patients admitted to hospital 'out of hours' wait twice as long to be assessed and suffer delays in getting brain scans and a bed, according to a new report. The study, covering NHS services in England and Northern Ireland, found 'good evidence' that people admitted on weekends, evenings and bank holidays suffer worse outcomes than those admitted during routine hours. Researchers found these patients wait twice as long on average to be assessed by a member of a stroke team (typically 188 minutes compared to 87 minutes for those admitted in hours). The delay in being given a dedicated stroke bed is also longer for patients admitted out of hours (234 minutes compared to 211 minutes) as is the delay to receiving a brain scan (170 minutes compared to 120 minutes). Accessing prompt care and treatment is essential to reducing the risk of death and disability from stroke, which affects around 150,000 people in the UK each year and kills about 53,000. The data further showed that patients who suffer a stroke while already … Continue reading

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Stanford researchers discover drug target for stimulating recovery from stroke

Posted: Published on March 22nd, 2012

Public release date: 21-Mar-2012 [ | E-mail | Share ] Contact: Bruce Goldman goldmanb@stanford.edu 650-725-2106 Stanford University Medical Center STANFORD, Calif. Investigators at the Stanford University School of Medicine have shown that removing a matched set of molecules that typically help to regulate the brain's capacity for forming and eliminating connections between nerve cells could substantially aid recovery from stroke even days after the event. In experiments with mice, the scientists demonstrated that when these molecules are not present, the mice's ability to recover from induced strokes improved significantly. Importantly, these beneficial effects grew over the course of a full week post-stroke, suggesting that, in the future, treatments such as drugs designed to reproduce the effects in humans might work even if given as much as several days after a stroke occurs. The only currently available stroke treatment tissue plasminogen activator, or tPA must be given within a few hours of a stroke to be effective, and patients' brains must first be scanned to determine whether this treatment is appropriate. Moreover, while tPA limits the initial damage caused by a stroke, it doesn't help the brain restore or replace lost connections between nerve cells, which is essential to recovery. The … Continue reading

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Drug target for stimulating recovery from stroke discovered

Posted: Published on March 22nd, 2012

ScienceDaily (Mar. 21, 2012) Investigators at the Stanford University School of Medicine have shown that removing a matched set of molecules that typically help to regulate the brain's capacity for forming and eliminating connections between nerve cells could substantially aid recovery from stroke even days after the event. In experiments with mice, the scientists demonstrated that when these molecules are not present, the mice's ability to recover from induced strokes improved significantly. Importantly, these beneficial effects grew over the course of a full week post-stroke, suggesting that, in the future, treatments such as drugs designed to reproduce the effects in humans might work even if given as much as several days after a stroke occurs. The only currently available stroke treatment -- tissue plasminogen activator, or tPA -- must be given within a few hours of a stroke to be effective, and patients' brains must first be scanned to determine whether this treatment is appropriate. Moreover, while tPA limits the initial damage caused by a stroke, it doesn't help the brain restore or replace lost connections between nerve cells, which is essential to recovery. The mice in the study had been genetically bioengineered to lack certain molecules that one of … Continue reading

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Parkinson's conference set for Myrtle Beach in April

Posted: Published on March 22nd, 2012

MYRTLE BEACH, SC -- To mark April as Parkinson's Awareness Month there will be a meeting at the Crown Reef April 19 that will feature representatives from the Medical University of South Carolina. The meeting -- from 9 a.m.-4 p.m. with registration at 8:30 a.m. -- will feature MUSC movement disorder department representatives Dr. Vanessa Hinson, Dr. Gonzalo Revuelta, Jennifer Zimmerman, RN, and Amy DeLambo, FNP, according to a release sent out on the meeting. Organizers will also honor people who have taken part in clinical trials to advance treatment of Parkinson. "There is estimated over a million people in the USA have Parkinson's. The reason for an estimate is we have no way of knowing the exact amount," Jackie Snead, assistant state director for Parkinson's Action Network and research advocate for Parkinson's Disease Foundation, said in a release on the event. "The main medication for treatment of Parkinson's is over 40 years old." Snead said in the release. For more information on the gathering, interested people can e-mail Snead at snead_jackie@yahoo.com. Continued here: Parkinson's conference set for Myrtle Beach in April … Continue reading

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Addex Reports Positive Top Line Phase IIa Data for Dipraglurant in Parkinson's Disease Levodopa-Induced Dyskinesia (PD …

Posted: Published on March 22nd, 2012

PLAN-LES-OUATES GENEVA, SWITZERLAND--(Marketwire -03/21/12)- Addex Therapeutics / Addex Reports Positive Top Line Phase IIa Data for Dipraglurant in Parkinson's Disease Levodopa-Induced Dyskinesia (PD-LID) Processed and transmitted by Thomson Reuters ONE. The issuer is solely responsible for the content of this announcement. Geneva, Switzerland, 21 March 2012 - Addex Therapeutics (SIX: ADXN), a leading company pioneering allosteric modulation-based drug discovery and development, announced today positive top line data from a Phase IIa clinical study of dipraglurant in Parkinson's disease (PD) patients suffering from debilitating levodopa-induced dyskinesia (LID). The data show that dipraglurant met the primary objective of the study by exhibiting a good safety and tolerability profile. Dipraglurant also demonstrated statistically significant reduction in LID severity with both 50mg and 100mg doses. Dipraglurant appears to reduce dystonia severity in addition to chorea, the two major LID components. A full analysis of the data will be presented at a scientific forum in 2012. Dipraglurant is an oral, small molecule allosteric modulator that inhibits selectively the metabotropic glutamate receptor 5 (mGluR5), a Class C G- Protein Coupled Receptor (GPCR), with potential to be used in combination with levodopa or dopamine agonists or as a standalone treatment for PD-LID, PD-related motor symptoms, non-motor symptoms … Continue reading

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Researchers discover protein mutation in Parkinson's disease

Posted: Published on March 22nd, 2012

Posted: Wednesday, March 21, 2012 10:00 am | Updated: 11:25 pm, Tue Mar 20, 2012. A recent discovery by Purdue researchers may open new doors in the treatment and detection of Parkinsons disease. The three year project concluded with the discovery of the cause of a mutation in protein DJ-1, which is directly correlated with the development of Parkinsons. This mutant protein has been known to exist in individuals with Parkinsons but the cause of the mutation, other than natural aging, has been unknown until now. Professor of chemistry Fred Regnier said, within the substantia nigra structure in the brain, DJ-1 serves as a chaperone for another protein known as alpha-synuclein. When DJ-1 is mutated, it becomes a less effective chaperone for alpha-synuclein. This results in clumps of protein called Lewy bodies, causing alpha-synuclein to stop functioning. This process, which causes Lewy bodies to build up, is referred to as oxidative stress. Too much oxidation can lead to oxidative stress diseases, which include Parkinsons. Anytime oxidative stress becomes very large, cells die for all kinds of reasons, Regnier said. The oxidative stress becomes so large that you begin to damage proteins. The discovery is not a cure for Parkinsons but … Continue reading

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Turmeric compound shows promise for Parkinson's treatment

Posted: Published on March 22nd, 2012

Washington, March 21 (ANI): Curcumin, a compound found in the spice turmeric, has been found to be effective at preventing clumping of a protein involved in Parkinson's disease. A team of researchers led by Basir Ahmad, a Michigan State University postdoctoral researcher, demonstrated earlier this year that slow-wriggling alpha-synuclein proteins are the cause of clumping, or aggregation, which is the first step of diseases such as Parkinson's. Now, a new study led by Ahmad has found that curcumin can help prevent clumping. "Our research shows that curcumin can rescue proteins from aggregation, the first steps of many debilitating diseases," said Lisa Lapidus, MSU associate professor of physics and astronomy who co-authored study with Ahmad. "More specifically, curcumin binds strongly to alpha-synuclein and prevents aggregation at body temperatures," she stated. Lapidus' lab uses lasers to study protein folding. Proteins are chains of amino acids that do most of the work in cells. Scientists understand protein structure, but they don't know how they are built - a process known as folding. Lapidus' team is shedding light on the process by correlating the speed at which protein folds with its tendency to clump or bind with other proteins. When curcumin attaches to alpha-synuclein … Continue reading

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