Parkinson’s patients advised to seek Deep Brain Stimulation treatment in early stages

People with Parkinson's disease who receive Deep Brain Stimulation (DBS) therapy in the early stages of the condition will benefit from a significant increase in quality of life, a revolutionary study from The New England Journal of Medicine has found.

Deep Brain Stimulation therapy - Animation from The University of Queensland on Vimeo.

World-leading neurologist and lead clinician Professor Peter Silburn from the Asia-Pacific Centre for Neuromodulation (APCN), a joint initiative of The University of Queensland (UQ) and St Andrew's Hospital, said the results published today in the medical journal would transform the way we treat people with Parkinson's disease.

Before the release of this study, a typical patient with Parkinson's disease would need to wait around 10 years or until their motor complications could no longer be treated successfully with medicine alone, before DBS surgery was considered an option, Professor Silburn said.

This study has confirmed the best medical practice for a person with Parkinson's disease is to perform DBS surgery around 4 to 7 years into the condition, as opposed to waiting until the medications stop working.

Participants in the EARLYSTIM trial had been experiencing symptoms of Parkinson's disease for an average of 7.5 years about five years less than participants in earlier trials allowing researchers to test the benefits of DBS therapy when motor fluctuations and dyskinesia are of recent onset and occupational and psychosocial competence is still maintained.

Key findings from these participants two years after receiving DBS therapy include: 26 percent improvement in their disease-related quality of life 53 percent improvement in motor skills 30 percent improvement in activities of daily life (speech, handwriting, dressing and walking) 61 percent improvement in levodopa-induced complications (including dyskinesias and motor fluctuations) 39 percent reduction in daily levodopa equivalent dosage.

Participants who did not undergo DBS surgery and received the best medical therapy only, experienced no improvement in their quality of life, no change in their motor skills, a 12 percent decline in their ability to perform daily activities, a 13 percent worsening in their levodopa-induced complications and a 21 percent increase in their daily levodopa equivalent dosage at two years.

As one of the world's top five centre's conducting DBS surgery, Professor Silburn said the APCN's responsibility to educate and train people in the delivery of DBS surgery has never been more important and patients should be aware of seeking advice from experienced DBS practitioners only.

One thing that may hinder this study from being adopted earlier in Australia is that very few neurologists and neurosurgeons have been trained in performing DBS surgery, Professor Silburn said.

View original post here:
Parkinson’s patients advised to seek Deep Brain Stimulation treatment in early stages