Pioneering Toronto scientists latest research to demystify stem cells

When Mount Sinai Hospital researcher Dr. Andras Nagy initiated a project to shine a light into the black box of turning specialized cells into stem cells, he wasnt expecting to find a whole new type of stem cell.

Nagy says identifying a new class of stem cells means a 100 per cent increase in possible sources of cells for therapeutic use.

He describes a stem cell as a blank tablet. They hold great potential to treat diseases that result from damaged tissue or loss of cells, such as Alzheimers, spinal cord injuries and blindness.

His latest research, dubbed Project Grandiose because of its sheer scale, aimed to demystify the process by which specialized cells turn into stem cells. Nagy worked with a team of close to 50 researchers across four continents to document this process. These cells called induced pluripotent stem cells, or iPS cells can be used to form any type of cell in the body as an alternative to using the more controversial stem cells from embryos.

The findings will be published Thursday in a package of papers in Nature and Nature Communications.

The oldest example of a therapy based on stem calls is bone marrow transplants, which have been performed for more than 40 years.

One of the newest applications of stem cells is treating and preventing the loss of vision using iPS cells. Japan has permitted the use of these cells to regenerate eye tissue this year. A woman in her 70s was the first to receive retinal tissue created from iPS cells to combat a degenerative condition that can lead to blindness.

Nagy characterizes this procedure as an icebreaker, hoping it will lead to further treatment and perhaps even cures in other diseases.

But understanding these cells first is key to safer use.

If we understand this process better and deeper, we will be in a better position to create safer and (more therapeutically useful) cell types in the future, said Nagy.

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Pioneering Toronto scientists latest research to demystify stem cells