This micrograph shows a single mitochondrion (yellow), one of many little energy factories inside a cell.
The federal government is considering whether to allow scientists to take a controversial step: make changes in some of the genetic material in a woman's egg that would be passed down through generations.
Mark Sauer of the Columbia University Medical Center, a member of one of two teams of U.S. scientists pursuing the research, calls the effort to prevent infants from getting devastating genetic diseases "noble." Sauer says the groups are hoping "to cure disease and to help women delivery healthy normal children."
But the research also raises a variety of concerns, including worries it could open the door to creating "designer babies." The Food and Drug Administration has scheduled an Oct. 22 hearing to consider the issues.
Specifically, the research would create an egg with healthy mitochondrial DNA (mtDNA). Unlike the DNA that most people are familiar with the 23 pairs of human chromosomes that program most of our body processes mtDNA is the bit of genetic material inside mitochondria, living structures inside a cell that provide its energy.
Scientists estimate that one in every 200 women carries defects in her mtDNA. Between one in 2,000 and one in 4,000 babies may be born each year with syndromes caused by these genetic glitches; the syndromes range from mild to severe. In many cases, there is no treatment and the affected child dies early in life.
Lori Martin, 33, of Houston, found out her son, Will, was born with the mitochondrial disease known as Leigh's syndrome, when he was about two years old.
Will Martin, with his mother, Lori. Will was 2 when Lori learned he was born with Leigh's Syndrome, a progressive genetic condition. So far it's given him low muscle tone and some difficulty with speech.
Will Martin, with his mother, Lori. Will was 2 when Lori learned he was born with Leigh's Syndrome, a progressive genetic condition. So far it's given him low muscle tone and some difficulty with speech.
"The experience of being told that your son is basically going to die and you don't know when or how it's obviously life-changing and it completely wrecks your world," Martin says.
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Proposed Treatment To Fix Genetic Diseases Raising Ethics Issues