Research improving lives for MS patients

Discovering new medicines is often the first thing that comes to mind when people think about clinical trials. But some of the most important research occurs in optimizing previously approved drugs. These follow-up studies are used to test the tolerability of drugs already approved, optimize patient safety and address patient acceptance.

An example of this type of research is underway now at The Corvallis Clinic involving patients who have multiple sclerosis. MS is a disease affecting the central nervous system, brain and spinal cord, causing problems with muscle control and strength, vision, balance, feeling and thinking.

The Clinics Research Center participated in a previous study to evaluate fingolimod, marketed as Gilenya, the first-ever pill for treating the most common form of the disease, relapsing remitting MS. With relapsing remitting MS, patients experience attacks or relapses of symptoms, which are followed by periods of partial or complete recovery. Prior to Gilenya, medication was only available by injection. Although most patients are able to give themselves shots at home, it was a pain and a literal discomfort. These shots were also leading to a compliance problem, with patients not wanting to take their medicine. In studies, patients taking Gilenya showed improved compliance.

From your doctors perspective, conducting research keeps medical providers involved in the latest treatment. Were interested in research for its potential to improve the quality of life for our patients. By participating in a research study, patients receive medication and study-related care at no cost to them. Improved access to care can also be a benefit for some patients.

Studies of MS are ongoing at our Research Center and elsewhere to stop the diseases progression and restore function. According to the National Multiple Sclerosis Society, there are more potential therapies in development now than ever.

MS is a relatively rare disease, and although it doesnt shorten the span of a persons life, it can greatly influence a persons capabilities, especially young people. In working with patients with MS, Ive seen the progress weve made in treating the disease.

The Corvallis Clinic has a long history of participating in clinical research. The first neurology studies were conducted here in the 1980s. When we started doing research, many of our study participants had more severe symptoms. Now our participants are often diagnosed sooner, have a milder form of the disease and are able to manage the disease with these new treatments.

Doctors used to think that damage to the nervous system couldnt be reversed. Now researchers are looking for ways to repair and restore function for people with MS. Others are looking for the cause of MS and to better understand what triggers it and how to protect against it.

We remain hopeful to be able to offer patients new medicines that will impact not only the management of MS, but also the outcome.

Dr. Richard Lafrance is a neurologist at The Corvallis Clinic. He can be reached at 541-754-1274.

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Research improving lives for MS patients