Sofroniew, M. V. Dissecting spinal cord regeneration. Nature 557, 343350 (2018).
Article ADS CAS Google Scholar
Anderson, M. A. et al. Natural and targeted circuit reorganization after spinal cord injury. Nature Neurosci. 25, 15841596 (2022).
Courtine, G. & Sofroniew, M. V. Spinal cord repair: advances in biology and technology. Nat. Med. 25, 898908 (2019).
Article CAS Google Scholar
Ahuja, C. S. et al. Traumatic spinal cord injury. Nat. Rev. Dis. Primers 3, 17018 (2017).
Article Google Scholar
Rowald, A. et al. Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis. Nat. Med. 28, 260271 (2022).
Article CAS Google Scholar
Squair, J. W. et al. Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury. Nature 590, 308314 (2021).
Article ADS CAS Google Scholar
Wagner, F. B. et al. Targeted neurotechnology restores walking in humans with spinal cord injury. Nature 563, 6571 (2018).
Article ADS CAS Google Scholar
Kathe, C. et al. The neurons that restore walking after paralysis. Nature 611, 540547 (2022).
Popovich, P. G., Wei, P. & Stokes, B. T. Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats. J. Comp. Neurol. 377, 443464 (1997).
Article CAS Google Scholar
Anderson, M. A. et al. Astrocyte scar formation aids central nervous system axon regeneration. Nature 532, 195200 (2016).
Article ADS CAS Google Scholar
Squair, J. W., Gautier, M., Sofroniew, M. V., Courtine, G. & Anderson, M. A. Engineering spinal cord repair. Curr. Opin. Biotech. 72, 4853 (2021).
Article CAS Google Scholar
Asboth, L. et al. Cortico-reticulo-spinal circuit reorganization enables functional recovery after severe spinal cord contusion. Nat. Neurosci. 21, 576588 (2018).
Article CAS Google Scholar
Scheff, S. W., Rabchevsky, A. G., Fugaccia, I., Main, J. A. & Lumpp, J. E. Experimental modeling of spinal cord injury: characterization of a force-defined injury device. J. Neurotraum. 20, 179193 (2003).
Article Google Scholar
Dusart, I. & Schwab, M. E. Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord. Eur. J. Neurosci. 6, 712724 (1994).
Article CAS Google Scholar
Zappia, L. & Oshlack, A. Clustering trees: a visualization for evaluating clusterings at multiple resolutions. Gigascience 7, giy083 (2018).
Article Google Scholar
Milich, L. M. et al. Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord. J. Exp. Med. 218, e20210040 (2021).
Article CAS Google Scholar
Sofroniew, M. V. & Vinters, H. V. Astrocytes: biology and pathology. Acta Neuropathol. 119, 735 (2010).
Article Google Scholar
Faulkner, J. R. et al. Reactive astrocytes protect tissue and preserve function after spinal cord injury. J. Neurosci. 24, 21432155 (2004).
Article CAS Google Scholar
Herrmann, J. E. et al. STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J. Neurosci. 28, 72317243 (2008).
Article CAS Google Scholar
Wanner, I. B. et al. Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury. J. Neurosci. 33, 1287012886 (2013).
Article CAS Google Scholar
Zheng, S. C. et al. Universal prediction of cell-cycle position using transfer learning. Genome Biol. 23, 41 (2022).
Article CAS Google Scholar
Munji, R. N. et al. Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core bloodbrain barrier dysfunction module. Nat. Neurosci. 22, 18921902 (2019).
Article CAS Google Scholar
Zeisel, A. et al. Molecular architecture of the mouse nervous system. Cell 174, 9991014.e22 (2018).
Article CAS Google Scholar
Yasuda, K. et al. Drug transporters on arachnoid barrier cells contribute to the bloodcerebrospinal fluid barrier. Drug Metab. Dispos. 41, 923931 (2013).
Article CAS Google Scholar
Dewar, D., Underhill, S. M. & Goldberg, M. P. Oligodendrocytes and ischemic brain injury. J. Cereb. Blood Flow Metabol. 23, 263274 (2002).
Article Google Scholar
Petracca, Y. L. et al. The late and dual origin of cerebrospinal fluid-contacting neurons in the mouse spinal cord. Development 143, 880891 (2016).
CAS Google Scholar
Vgh, B. et al. The system of cerebrospinal fluid-contacting neurons. Its supposed role in the nonsynaptic signal transmission of the brain. Histol. Histopathol. 19, 607628 (2004).
Google Scholar
Squair, J. W. et al. Recovery of walking after paralysis by regenerating characterized neurons to their natural target region. Science 381, 13381345 (2023).
Courtine, G. et al. Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury. Nat. Med. 14, 6974 (2008).
Article CAS Google Scholar
Skinnider, M. A. et al. Cell type prioritization in single-cell data. Nat. Biotechnol. 39, 3034 (2021).
Article CAS Google Scholar
Squair, J. W., Skinnider, M. A., Gautier, M., Foster, L. J. & Courtine, G. Prioritization of cell types responsive to biological perturbations in single-cell data with Augur. Nat. Protoc. 16, 38363873 (2021).
Renthal, W. et al. Transcriptional reprogramming of distinct peripheral sensory neuron subtypes after axonal injury. Neuron 108, 128144.e9 (2020).
Nguyen, M. Q., Pichon, C. E. L. & Ryba, N. Stereotyped transcriptomic transformation of somatosensory neurons in response to injury. eLife 8, e49679 (2019).
Article Google Scholar
Cajal, S. R. Y. & May, R. M. Cajals Degeneration and Regeneration of the Nervous System (Oxford Univ. Press, 1991).
Sperry, R. W. Chemoaffinity in the orderly growth of nerve fiber patterns and connections. Proc. Natl Acad. Sci. USA 50, 703710 (1963).
Article ADS CAS Google Scholar
Cajal, S. R. Y. Degeneration and Regeneration of the Nervous System (Oxford Univ. Press, 1928).
Anderson, M. A. et al. Required growth facilitators propel axon regeneration across complete spinal cord injury. Nature 561, 396400 (2018).
Article ADS CAS Google Scholar
Harel, N. Y. & Strittmatter, S. M. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury?. Nat. Rev. Neurosci. 7, 603616 (2006).
Article CAS Google Scholar
Mironova, Y. A. & Giger, R. J. Where no synapses go: gatekeepers of circuit remodeling and synaptic strength. Trends Neurosci. 36, 363373 (2013).
Article CAS Google Scholar
Lin, A. C. & Holt, C. E. Local translation and directional steering in axons. EMBO J. 26, 37293736 (2007).
Article CAS Google Scholar
Short, D., Masry, W. E. & Jones, P. High dose methylprednisolone in the management of acute spinal cord injurya systematic review from a clinical perspective. Spinal Cord 38, 273286 (2000).
Article CAS Google Scholar
Bracken, M. B. Efficacy of methylprednisolone in acute spinal cord injury. JAMA 251, 45 (1984).
Article CAS Google Scholar
Hurlbert, R. J. Methylprednisolone for acute spinal cord injury: an inappropriate standard of care. J. Neurosurg. Spine 93, 17 (2000).
Article CAS Google Scholar
Klein, S. L. & Flanagan, K. L. Sex differences in immune responses. Nat. Rev. Immunol. 16, 626638 (2016).
Article CAS Google Scholar
Gal-Oz, S. T. et al. ImmGen report: sexual dimorphism in the immune system transcriptome. Nat. Commun. 10, 4295 (2019).
Article ADS Google Scholar
Mattucci, S. et al. Basic biomechanics of spinal cord injuryhow injuries happen in people and how animal models have informed our understanding. Clin. Biomech. 64, 5868 (2018).
Article Google Scholar
OShea, T. M. et al. Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype in mice. Nat. Commun. 13, 5702 (2022).
Article ADS Google Scholar
Squair, J. W. et al. Confronting false discoveries in single-cell differential expression. Nat. Commun. 12, 5692 (2021).
Article ADS CAS Google Scholar
Granja, J. M. et al. ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis. Nat. Genet. 53, 403411 (2021).
Article CAS Google Scholar
Kang, J. B. et al. Efficient and precise single-cell reference atlas mapping with Symphony. Nat. Commun. 12, 5890 (2021).
Article ADS CAS Google Scholar
Schep, A. N., Wu, B., Buenrostro, J. D. & Greenleaf, W. J. chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data. Nat. Methods 14, 975978 (2017).
Article CAS Google Scholar
Schwarzschild, M. A., Cole, R. L. & Hyman, S. E. Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons. J. Neurosci. 17, 34553466 (1997).
Article CAS Google Scholar
Burda, J. E. et al. Divergent transcriptional regulation of astrocyte reactivity across disorders. Nature 606, 557564 (2022).
Pollard, K. S., Hubisz, M. J., Rosenbloom, K. R. & Siepel, A. Detection of nonneutral substitution rates on mammalian phylogenies. Genome Res. 20, 110121 (2010).
Article CAS Google Scholar
More:
Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica - Nature.com
- Hungarian Spinal Cord Injury Patient - Stem Cell Treatment Experience [Last Updated On: May 7th, 2011] [Originally Added On: May 7th, 2011]
- Stem cell treatment for Spinal Cord Injury (SCI)-Osama [Last Updated On: May 8th, 2011] [Originally Added On: May 8th, 2011]
- Spinal Cord Injury Patient after Stem Cell Treatment - Juan Carlos Murillo [Last Updated On: May 10th, 2011] [Originally Added On: May 10th, 2011]
- Spinal Cord Injury patient 10 years after injury after Stem Cell Treatment [Last Updated On: May 10th, 2011] [Originally Added On: May 10th, 2011]
- Rap Toward a Cure for Spinal Cord Injury [Last Updated On: May 11th, 2011] [Originally Added On: May 11th, 2011]
- Christopher "Kit" Bond - Spinal Cord Injury Stem Cell Patient [Last Updated On: May 20th, 2011] [Originally Added On: May 20th, 2011]
- Stem Cell Treatment - Spinal Cord Injury (2) [Last Updated On: May 21st, 2011] [Originally Added On: May 21st, 2011]
- Spinal Cord Injury-After Treatment, Pt was completely paralyzed (2) [Last Updated On: May 22nd, 2011] [Originally Added On: May 22nd, 2011]
- Spinal Cord Injury-After Treatment, Pt was completely paralyzed (1) [Last Updated On: May 23rd, 2011] [Originally Added On: May 23rd, 2011]
- Dogs recover following new treatment for spinal cord injury [Last Updated On: June 2nd, 2011] [Originally Added On: June 2nd, 2011]
- Spinal Cord Injury Rehabiliation Success Story [Last Updated On: June 3rd, 2011] [Originally Added On: June 3rd, 2011]
- Stem Cells for Spinal Cord Injury: Community Outreach San Diego 2011 - Trish Stressman [Last Updated On: June 7th, 2011] [Originally Added On: June 7th, 2011]
- Stroke Client Gains Strength and Mobility in North Palm Beach Florida [Last Updated On: June 9th, 2011] [Originally Added On: June 9th, 2011]
- Spinal Cord Injury Chicago Rehabilitation Lokomat [Last Updated On: June 10th, 2011] [Originally Added On: June 10th, 2011]
- Spinal Cord Injury Treatment With Stem Cells [Last Updated On: June 11th, 2011] [Originally Added On: June 11th, 2011]
- Spinal Cord Injury Patient after Stem Cell Treatment - Wesley Hixen [Last Updated On: June 12th, 2011] [Originally Added On: June 12th, 2011]
- Stem Cell Therapy for Spinal Cord Injury - Injured Airline Pilot Flies Again [Last Updated On: June 13th, 2011] [Originally Added On: June 13th, 2011]
- David Chen: How would stem-cell therapies work in the treatment of spinal cord injuries? [Last Updated On: June 17th, 2011] [Originally Added On: June 17th, 2011]
- William Rader MD - Paralyzed Spinal Cord Injury Patient Walks Again [Last Updated On: June 29th, 2011] [Originally Added On: June 29th, 2011]
- The Spinal Cord Injury Treatment Team [Last Updated On: July 4th, 2011] [Originally Added On: July 4th, 2011]
- Introduction to the Bioness H200 Hand Rehabilitation System [Last Updated On: July 14th, 2011] [Originally Added On: July 14th, 2011]
- Organ repair using own stem cells -- brain, heart - Future Health keynote speaker [Last Updated On: July 15th, 2011] [Originally Added On: July 15th, 2011]
- 2011 Shriners Ride for Kids, Salt Lake City Utah. [Last Updated On: July 17th, 2011] [Originally Added On: July 17th, 2011]
- Degenerative Disc Disease: C5-C6 c6-C7 Treatment [Last Updated On: July 18th, 2011] [Originally Added On: July 18th, 2011]
- Rehabilitation Institute of Michigan's 60 Anniversary TV Commercial [Last Updated On: July 18th, 2011] [Originally Added On: July 18th, 2011]
- California Spinal Cord Injury Attorney: Obtaining damages for lifetime care. [Last Updated On: July 19th, 2011] [Originally Added On: July 19th, 2011]
- Physical and Mental Adjustments After a Spinal Cord Injury [Last Updated On: July 19th, 2011] [Originally Added On: July 19th, 2011]
- Comprehensive Inpatient Rehabilitation [Last Updated On: July 28th, 2011] [Originally Added On: July 28th, 2011]
- SCI Treatment Center at the Claremont Club [Last Updated On: July 30th, 2011] [Originally Added On: July 30th, 2011]
- Spinal Cord Inury Patient at XCell-Center- M. Hasan [Last Updated On: August 5th, 2011] [Originally Added On: August 5th, 2011]
- Spinal Cord Inury Patient at XCell-Center- K. Potts [Last Updated On: August 6th, 2011] [Originally Added On: August 6th, 2011]
- Magee Rehabilitation Hospital Foundation and Toyota 100 Cars for Good [Last Updated On: August 13th, 2011] [Originally Added On: August 13th, 2011]
- SCI_Celine_French_ifting_her_arms.wmv [Last Updated On: September 1st, 2011] [Originally Added On: September 1st, 2011]
- New Treatment May Help Paralyzed Patients Move Again By Dr.Zaghloul ahmed [Last Updated On: September 1st, 2011] [Originally Added On: September 1st, 2011]
- Claire Marsh - Spinal Cord Injury Part One [Last Updated On: September 6th, 2011] [Originally Added On: September 6th, 2011]
- Coping with spinal cord and traumatic brain injuries [Last Updated On: September 10th, 2011] [Originally Added On: September 10th, 2011]
- Stem Cell Treatment - Spinal Cord Injury (3) [Last Updated On: September 15th, 2011] [Originally Added On: September 15th, 2011]
- Stem Cell Treatment - Spinal Cord Injury (1) [Last Updated On: September 20th, 2011] [Originally Added On: September 20th, 2011]
- Stem cell treatment by Adiva Health Care India after Spinal Cord Injury [Last Updated On: September 22nd, 2011] [Originally Added On: September 22nd, 2011]
- Spinal Cord Injury Documentary: You Will Never Walk Again, Part 1 [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- Claire Marsh Returns - Spinal Cord Injury Patient [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- Spinal Cord Injury: Raising awareness about research and treatment for spinal cord injury [Last Updated On: September 26th, 2011] [Originally Added On: September 26th, 2011]
- Walking after Spinal Cord injury and Stem Cells [Last Updated On: September 27th, 2011] [Originally Added On: September 27th, 2011]
- New Treatments for Spinal Cord Injuries [Last Updated On: October 10th, 2011] [Originally Added On: October 10th, 2011]
- Claire Marsh - Spinal Cord Injury Part Two - Video [Last Updated On: October 18th, 2011] [Originally Added On: October 18th, 2011]
- Stem Cell Treatment for Spinal Cord Injury - Video [Last Updated On: November 2nd, 2011] [Originally Added On: November 2nd, 2011]
- Stem Cells - Treatment for Spinal Cord Injury - Video [Last Updated On: November 2nd, 2011] [Originally Added On: November 2nd, 2011]
- (Film Trailer) - The Spinal Cord Journey: Stem Cell Therapy Stories of Recovery - Video [Last Updated On: November 27th, 2011] [Originally Added On: November 27th, 2011]
- Stem Cell Treatment for T-6 Spinal Cord Injury - Video [Last Updated On: December 7th, 2011] [Originally Added On: December 7th, 2011]
- What is Project Walk Atlanta - Video [Last Updated On: December 13th, 2011] [Originally Added On: December 13th, 2011]
- Stem Cells Treatment for Spinal Cord Injuries, Successfully Results, Stem Therapy - Video [Last Updated On: December 28th, 2011] [Originally Added On: December 28th, 2011]
- Stem Cell Therapy for Spinal Cord Injury, India Mumbai - Video [Last Updated On: January 6th, 2012] [Originally Added On: January 6th, 2012]
- "April Crave", "Project Walk Spinal Cord Injury Recovery" - Video [Last Updated On: January 10th, 2012] [Originally Added On: January 10th, 2012]
- "Lori Hammond", "Project Walk Spinal Cord Injury Recovery" - Video [Last Updated On: January 23rd, 2012] [Originally Added On: January 23rd, 2012]
- "Chad C.""spinal cord Injury treatment" "spinal cord injury" "spinal cord injury recovery" - Video [Last Updated On: January 23rd, 2012] [Originally Added On: January 23rd, 2012]
- "Hugo Rodovalho", "Client Spotlight Project Walk Spinal Cord Injury Recovery" - Video [Last Updated On: January 27th, 2012] [Originally Added On: January 27th, 2012]
- "Cecilia V.", "Project Walk Spinal Cord Injury Recovery" - Video [Last Updated On: January 27th, 2012] [Originally Added On: January 27th, 2012]
- "Roy R.", "Project Walk Spinal Cord Injury Recovery" - Video [Last Updated On: January 27th, 2012] [Originally Added On: January 27th, 2012]
- "Angela", "Project Walk Spinal Cord Injury Recovery" - Video [Last Updated On: January 27th, 2012] [Originally Added On: January 27th, 2012]
- "Joey's Story", "Project Walk Spinal Cord Injury Recovery" - Video [Last Updated On: January 27th, 2012] [Originally Added On: January 27th, 2012]
- "Spinal Cord Injury", "A Story Of One" - Video [Last Updated On: January 27th, 2012] [Originally Added On: January 27th, 2012]
- Spinal Cord Injuries - The Healing Center Project! - Video [Last Updated On: January 28th, 2012] [Originally Added On: January 28th, 2012]
- "Crystal H.", "Project Walk Spinal Cord Injury Recovery" - Video [Last Updated On: February 3rd, 2012] [Originally Added On: February 3rd, 2012]
- "Dave D.", "Project Walk Spinal Cord Injury Recovery" - Video [Last Updated On: February 5th, 2012] [Originally Added On: February 5th, 2012]
- "Brook", "Project Walk Spinal Cord Injury Recovery" - Video [Last Updated On: February 5th, 2012] [Originally Added On: February 5th, 2012]
- "Ashley Vargas", "Project Walk Spinal Cord Injury Recovery" - Video [Last Updated On: February 6th, 2012] [Originally Added On: February 6th, 2012]
- "Nathan Bayer", "Project Walk Spinal Cord Injury Recovery" - Video [Last Updated On: February 8th, 2012] [Originally Added On: February 8th, 2012]
- "Annette Ross", "Project Walk Spinal Cord Injury Recovery" - Video [Last Updated On: February 8th, 2012] [Originally Added On: February 8th, 2012]
- "Joe Guintu", "Project Walk Spinal Cord Injury Recovery" - Video [Last Updated On: February 8th, 2012] [Originally Added On: February 8th, 2012]
- "Trevor Comeau,"Project Walk Spinal Cord Injury Recovery" - Video [Last Updated On: February 9th, 2012] [Originally Added On: February 9th, 2012]
- "Kyle Eade, "Project Walk Spinal Cord Injury Recovery" - Video [Last Updated On: February 11th, 2012] [Originally Added On: February 11th, 2012]
- Velomedix Receives IDE Approval to Evaluate the Use of Rapid Therapeutic Hypothermia in the Management of AMI Patients [Last Updated On: February 14th, 2012] [Originally Added On: February 14th, 2012]
- Neuralstem Announces Closing of $5.2-Million Registered Direct Offering [Last Updated On: February 14th, 2012] [Originally Added On: February 14th, 2012]
- Chamber May Open Window for Treating Spine [Last Updated On: February 15th, 2012] [Originally Added On: February 15th, 2012]
- InVivo Therapeutics’ CEO Frank Reynolds Scheduled to Appear on Fox News First and San Antonio Living [Last Updated On: February 17th, 2012] [Originally Added On: February 17th, 2012]
- High doses of 'load' slows loss of bone in spinal cord injury [Last Updated On: February 17th, 2012] [Originally Added On: February 17th, 2012]
- InVivo Therapeutics Announces Pricing of Public Offering of Common Stock [Last Updated On: February 17th, 2012] [Originally Added On: February 17th, 2012]
- High Doses of Load Slows Bone Loss in Spinal Cord Injury [Last Updated On: February 21st, 2012] [Originally Added On: February 21st, 2012]
- InVivo Therapeutics Announces Full Exercise of Over-Allotment Option [Last Updated On: February 22nd, 2012] [Originally Added On: February 22nd, 2012]
- InVivo Therapeutics Announces Net $18.1M In Offering [Last Updated On: February 22nd, 2012] [Originally Added On: February 22nd, 2012]