For more than 17 million people in the United States living with severe eczema a condition that results in dry, itchy rashes and disqualifies many from military service the mystery behind its cause may be all too familiar. Thanks to researchers at the Uniformed Services University of Health Sciences and National Institutes of Health, certain patients may understand more about their condition.
Studying these disorders, especially when we can define the disease based on a single mutation, is incredibly informative because you can learn a lot, said Andrew Snow, assistant professor in the department of pharmacology and molecular therapeutics at USU, and senior co-author of a study recently published in the journal Nature Genetics.
In this study, mutations in a gene known as CARD11 were identified as one underlying cause for severe eczema. The discovery led the researchers to ask whether excess glutamine can help correct some of the allergy-related defects in patients immune cells. The testing was done with T cells, known as the conductors of the bodys immune response against infections, from one patient in a lab, and the results were promising. Additional work with the NIH to study whether symptoms for patients with similar mutations improve with glutamine supplements a readily available product in stores is likely, Snow said.
Severe eczema can run in Families, which suggests a genetic cause, said Snow. One by one, Snow and NIH allergist Dr. Joshua Milner received referrals for patients who had mutations in the same gene totaling eight patients from four different Families.
However, such treatments are not a cure for the cause of the disease, particularly if its a genetic cause, Snow said.
During the study, researchers discovered these CARD11 mutations can prevent T cells from being able to do their jobs normally. The mutations prevent the cells from taking in enough glutamine, which is needed for T cells to maintain their proper function. This may help explain why some patients with severe eczema have a history of pneumonia, warts, and other types of lung and skin infections, Snow said.
While a mutation in the CARD11 gene is only one possible cause for severe eczema, its discovery can influence new therapies. Current treatments, including over-the-counter and prescription pills or creams, focus on bringing down the inflammation and relieving the itching.
Jeffrey Stinson, a former USU graduate student in Snows laboratory, who is currently at the National Institute of Standards and Technology and co-author on the study, said the possibility of having something so easily accessible as a targeted form of treatment would be an incredible achievement for those living with severe eczema and other allergic symptoms.
This genetic condition is considered rare, but its important to acknowledge the impact that findings from small, basic research studies like this can have in the medical field, Stinson said, stressing that the research would not be possible without the time and participation of the Families who volunteer. Thanks to their dedication, we have new and exciting possibilities for advancement before us.
View post:
SKIN HEALTH: Skin condition research | Post Life ... - The Fort Campbell Courier
- Eczema: Read About Symptoms and Medications [Last Updated On: October 15th, 2014] [Originally Added On: October 15th, 2014]
- Dermatitis - Wikipedia, the free encyclopedia [Last Updated On: October 15th, 2014] [Originally Added On: October 15th, 2014]
- Eczema and Your Skin | Eczema Types, Symptoms, Causes, and ... [Last Updated On: October 15th, 2014] [Originally Added On: October 15th, 2014]
- Kangen Water Testimony - Eczema, Weight Loss, Headaches - Video [Last Updated On: October 15th, 2014] [Originally Added On: October 15th, 2014]
- Controlling eczema - Video [Last Updated On: October 17th, 2014] [Originally Added On: October 17th, 2014]
- Eczema update! - When To Seek Medical Attention - Video [Last Updated On: October 18th, 2014] [Originally Added On: October 18th, 2014]
- My Makeup Routine For Eczema & Psoriasis - Video [Last Updated On: October 18th, 2014] [Originally Added On: October 18th, 2014]
- Dyson launches humidifier to combat eczema and psoriasis [Last Updated On: October 20th, 2014] [Originally Added On: October 20th, 2014]
- Sanofi, Regeneron Begin Phase 3 Study For Eczema Drug Dupilumab [Last Updated On: October 20th, 2014] [Originally Added On: October 20th, 2014]
- Ayurvedic treatment for Atopic Eczema - Video [Last Updated On: October 20th, 2014] [Originally Added On: October 20th, 2014]
- How To Treating Eczema at Home? EASY! Find it On This Video - Video [Last Updated On: October 20th, 2014] [Originally Added On: October 20th, 2014]
- Topical BioMedics Announces "Soothe the Skin They're in," a New Program for Children Who Suffer with Eczema [Last Updated On: October 21st, 2014] [Originally Added On: October 21st, 2014]
- Vitamin D Might Help Kids With Eczema [Last Updated On: October 21st, 2014] [Originally Added On: October 21st, 2014]
- Edguard tube cream for acne, eczema, scars and pregnancy blemishes - Video [Last Updated On: October 21st, 2014] [Originally Added On: October 21st, 2014]
- Cara Veldman #1848200 Eczema Cream - Video [Last Updated On: October 21st, 2014] [Originally Added On: October 21st, 2014]
- Tampa dermatologists clinical trial for sufferers of eczema ongoing [Last Updated On: October 23rd, 2014] [Originally Added On: October 23rd, 2014]
- Eczema - A recurrent rash everyone complains about [Last Updated On: October 23rd, 2014] [Originally Added On: October 23rd, 2014]
- My Essentials for Dry Skin & Eczema - Video [Last Updated On: October 23rd, 2014] [Originally Added On: October 23rd, 2014]
- Taking a 'Selfie' May Help With Dermatology Care, Study Shows [Last Updated On: October 24th, 2014] [Originally Added On: October 24th, 2014]
- EP.2 Cures Thermales : Business ou Sant ? - EczemaHelp - Video [Last Updated On: October 24th, 2014] [Originally Added On: October 24th, 2014]
- EP.1 Cures Thermales : Business ou Sant ? - EczemaHelp - Video [Last Updated On: October 24th, 2014] [Originally Added On: October 24th, 2014]
- Home remedy for eczema - Beat eczema - Video [Last Updated On: October 24th, 2014] [Originally Added On: October 24th, 2014]
- Trailer - EczemaHelp - Video [Last Updated On: October 24th, 2014] [Originally Added On: October 24th, 2014]
- Family First: Calming the symptoms of severe eczema [Last Updated On: October 25th, 2014] [Originally Added On: October 25th, 2014]
- what causes eczema - Eczema Free Providing ... [Last Updated On: October 27th, 2014] [Originally Added On: October 27th, 2014]
- Atopic eczema - Treatment - NHS Choices - Your health ... [Last Updated On: October 27th, 2014] [Originally Added On: October 27th, 2014]
- Atopic dermatitis - Wikipedia, the free encyclopedia [Last Updated On: October 27th, 2014] [Originally Added On: October 27th, 2014]
- Atopic eczema - NHS Choices [Last Updated On: October 27th, 2014] [Originally Added On: October 27th, 2014]
- Eczema Treatment Options : How To Cure Eczema & Home Remedies For Eczema - Video [Last Updated On: October 27th, 2014] [Originally Added On: October 27th, 2014]
- Chamomile: A herbal medicine of the past with bright future [Last Updated On: October 29th, 2014] [Originally Added On: October 29th, 2014]
- How SELFIES can help cure skin conditions [Last Updated On: October 30th, 2014] [Originally Added On: October 30th, 2014]
- Eczema linked to bone fractures, injuries in new Northwestern study [Last Updated On: October 30th, 2014] [Originally Added On: October 30th, 2014]
- Adult eczema may be unrecognized risk factor for fracture, other injuries [Last Updated On: October 30th, 2014] [Originally Added On: October 30th, 2014]
- Mom Tips: Relief for Baby Eczema - Video [Last Updated On: October 30th, 2014] [Originally Added On: October 30th, 2014]
- BEST BABY ECZEMA PRODUCTS - Video [Last Updated On: October 30th, 2014] [Originally Added On: October 30th, 2014]
- Eczema Tied to Bone Fracture Risk in Study [Last Updated On: October 30th, 2014] [Originally Added On: October 30th, 2014]
- Accident prone eczema patients [Last Updated On: October 30th, 2014] [Originally Added On: October 30th, 2014]
- Eczema girl's agony is over thanks to allergen-busting extra washing machine rinse cycles [Last Updated On: November 1st, 2014] [Originally Added On: November 1st, 2014]
- Helping Healing Eva's Eczema with Applied Kinesiology - Video [Last Updated On: November 1st, 2014] [Originally Added On: November 1st, 2014]
- Eczema May Increase Risk of Injury - Video [Last Updated On: November 1st, 2014] [Originally Added On: November 1st, 2014]
- treatmyeczema [Last Updated On: November 2nd, 2014] [Originally Added On: November 2nd, 2014]
- My Eczema Care Routine March 2014 | ... ... [Last Updated On: November 2nd, 2014] [Originally Added On: November 2nd, 2014]
- The Psoriasis Eczema Skin Puzzle #42 - Video [Last Updated On: November 3rd, 2014] [Originally Added On: November 3rd, 2014]
- Can some patients' bodies become 'addicted' to topical steroids? [Last Updated On: November 5th, 2014] [Originally Added On: November 5th, 2014]
- How To Treat Eczema Naturally Review DO NATURAL REMEDIES REALLY WORK - Video [Last Updated On: November 5th, 2014] [Originally Added On: November 5th, 2014]
- I Will Beat Anyone I Find Eczema On His/Her Body - Video [Last Updated On: November 5th, 2014] [Originally Added On: November 5th, 2014]
- Proper amount of bathing and moisturizing your baby may help prevent skin disease [Last Updated On: November 8th, 2014] [Originally Added On: November 8th, 2014]
- How to get rid of super dry skin psoriasis, eczema and more! - Video [Last Updated On: November 12th, 2014] [Originally Added On: November 12th, 2014]
- Easy Homemade Remedy For Eczema - Pulse Daily - Video [Last Updated On: November 13th, 2014] [Originally Added On: November 13th, 2014]
- Aveeno Eczema Therapy Moisturizing Cream - Video [Last Updated On: November 15th, 2014] [Originally Added On: November 15th, 2014]
- aveeno eczema moisturizing cream | Sample Promo - Video [Last Updated On: November 16th, 2014] [Originally Added On: November 16th, 2014]
- Psoriasis & Eczema : Rain soul by Johnny - Video [Last Updated On: November 16th, 2014] [Originally Added On: November 16th, 2014]
- aveeno baby eczema therapy moisturising cream | Sample Promo - Video [Last Updated On: November 17th, 2014] [Originally Added On: November 17th, 2014]
- aveeno baby eczema therapy reviews | Sample Promo - Video [Last Updated On: November 18th, 2014] [Originally Added On: November 18th, 2014]
- Peanut in household dust linked to peanut allergies, especially for children with eczema [Last Updated On: November 19th, 2014] [Originally Added On: November 19th, 2014]
- Peanut in household dust linked to peanut allergy in children with eczema during infancy [Last Updated On: November 19th, 2014] [Originally Added On: November 19th, 2014]
- 10 Tips to Manage Psoriasis and Eczema this Winter [Last Updated On: November 19th, 2014] [Originally Added On: November 19th, 2014]
- Tampa dermatologist excited over eczema clinical trial results [Last Updated On: November 20th, 2014] [Originally Added On: November 20th, 2014]
- aveeno baby eczema moisturizing cream | Sample Promo - Video [Last Updated On: November 20th, 2014] [Originally Added On: November 20th, 2014]
- Why I am sharing my eczema journey and what I deal with everyday living with eczema - Video [Last Updated On: November 20th, 2014] [Originally Added On: November 20th, 2014]
- Cetaphil Restoraderm Restoring Formulated Eczema - Video [Last Updated On: November 20th, 2014] [Originally Added On: November 20th, 2014]
- Cetaphil Restoraderm Restoring Moisturizer 10 Fluid - Video [Last Updated On: November 20th, 2014] [Originally Added On: November 20th, 2014]
- Childhood Eczema Cure With Kangen Water - Testimonial - Video [Last Updated On: November 22nd, 2014] [Originally Added On: November 22nd, 2014]
- Natural Remedies for Eczema - The Best Eczema Treatment - Video [Last Updated On: November 23rd, 2014] [Originally Added On: November 23rd, 2014]
- Eczema in Kids - Read More About It - Video [Last Updated On: November 23rd, 2014] [Originally Added On: November 23rd, 2014]
- Hypoallergenic labels may not be accurate [Last Updated On: November 23rd, 2014] [Originally Added On: November 23rd, 2014]
- Danielle Sheehan's life transformed after Botox eradicates her eczema [Last Updated On: November 25th, 2014] [Originally Added On: November 25th, 2014]
- Eczema's effects can be bone-deep [Last Updated On: November 25th, 2014] [Originally Added On: November 25th, 2014]
- New recommendations for treating kids with eczema [Last Updated On: November 25th, 2014] [Originally Added On: November 25th, 2014]
- Eczema cases rising among U.S. children [Last Updated On: November 25th, 2014] [Originally Added On: November 25th, 2014]
- Eczema Cases Rising Among U.S. Children: Report [Last Updated On: November 25th, 2014] [Originally Added On: November 25th, 2014]
- New guidelines released for treating kids with eczema - Video [Last Updated On: November 25th, 2014] [Originally Added On: November 25th, 2014]
- TCM Recipe Natural Herbal Eczema Cream Review - Video [Last Updated On: November 25th, 2014] [Originally Added On: November 25th, 2014]
- New product to heal eczema to use topically and progress pictures - Video [Last Updated On: November 25th, 2014] [Originally Added On: November 25th, 2014]
- 15 Proven Natural Cures for Eczema - Baby dermatitis: how ... [Last Updated On: November 26th, 2014] [Originally Added On: November 26th, 2014]
- Aveeno Moisturizing Bar - Aveeno Eczema Therapy Moisturizing Cream - Video [Last Updated On: November 26th, 2014] [Originally Added On: November 26th, 2014]
- How to psychologically & physically confront eczema in you. - Video [Last Updated On: November 26th, 2014] [Originally Added On: November 26th, 2014]
- Woman, 21, left looking sunburnt by severe eczema finally has the perfect complexion - thanks to a 'magical' cream [Last Updated On: November 27th, 2014] [Originally Added On: November 27th, 2014]
- Aveeno Baby Sunscreen - Aveeno Baby Coupons - Aveeno Baby Eczema - Video [Last Updated On: November 27th, 2014] [Originally Added On: November 27th, 2014]
- How I cured my eczema in just over 10 days and you can to. My personal review - Video [Last Updated On: November 28th, 2014] [Originally Added On: November 28th, 2014]