Stanford researchers have several projects underway to improve imaging techniques, bracing treatment and surgeries for kids and teens with scoliosis.
Scoliosis is a common condition in which the spine twists and curves sideways instead of running straight down the center of the back.
More than 1 in every 100 adolescents is diagnosed with scoliosis, but it can also occur in younger children. A large spinal curve can cause deformities, pain and muscle spasms, and can even hinder breathing by limiting space for the rib cage and lungs to expand.
Stanford pediatric orthopedic surgeon John Vorhies, MD, who sees scoliosis patients through the Spine Program at Lucile Packard Children's Hospital Stanford, is conducting several research projects to improve treatments for these kids and teens.
I talked to him recently about what drew him to the field and what research he's excited about now. This Q&A has been edited and condensed for clarity.
Why did you decide to become a pediatric orthopedic surgeon?
I initially thought I would be an internal medicine or infectious disease doctor, but I realized that the day-to-day work in those specialties is less hands-on than I wanted. I'm interested in art and sculpture; I did ceramics for many years and enjoy using my hands.
In pediatric orthopedic surgery, you have the technical elements of any surgical specialty, but there is also this element of growth. In anything you do, you have to think about how much a child is going to grow, and how that's going to affect their healing and your work. It's exciting because patients have so many years to benefit from what we do.
And I enjoy working with kids. In medical school you spend time in a lot of different clinics, and I was always happier in pediatrics. Kids are funny! I could joke with them and they'd laugh.
Why have you chosen to specialize in scoliosis?
Treating scoliosis gives me the opportunity to care for a broad range of patients, from healthy adolescents who are high-performing athletes and have nothing else medically wrong, to infants and small kids under age 5.
It's a tougher disease when it starts early, when they have so many years ahead, but that means the interventions we offer are much more meaningful.
I also see patients with other medical needs, such as cerebral palsy or muscular dystrophy. These children may already have lung problems when they develop scoliosis, putting them at risk for further breathing problems. Worsening scoliosis can lead to frequent hospitalizations or a need for ventilation. But by operating, I can halt its progression, and that can improve many parts of patients' lives and can even extend their lives.
Within orthopedic surgery, scoliosis cases represent the highest-risk, longest operations we perform, so it's a high-impact area for research to make our interventions safer and more effective.
Around 5-10% of kids and teens with scoliosis need treatment that often includes wearing a brace on the torso that pushes on their ribs and spine as they grow. How is your research addressing bracing?
Wearing a hard plastic brace for 12-18 hours a day is tough. You have to wear it to sleep and at school, but can take it off for sports and some other activities. The success of the treatment directly correlates to how long it's worn.
We're studying how to encourage people to wear their brace as prescribed. One study, with my colleague Kali Tileston, MD, asks which patients are at risk for not wearing their brace, based on the psychological concept of growth mindset. We survey patients to gauge their concept of their own health: Is it something that they think they can change? That's been shown to affect adherence to treatment and offers an opportunity for us to intervene.
We also use body-heat sensors that track how long a patient wears their brace. Patients are generally very excited about getting real data on how they're doing -- it gives them self-motivation. For adolescents, it's very hard to do something so taxing for a long-term goal, so we're thinking about how to link brace data to short-term rewards for them.
With Stanford biomedical engineers and my fellow surgeon Carla Pugh, MD, we are also designing sensors that go inside the brace to measure how much pressure it puts on different parts of body. Is it pressing hard enough to give results, but not so hard that it's uncomfortable? That project is in pre-clinical testing. Both this project and our mindset research have funding from the Scoliosis Research Society.
You also have a project that creates 3D maps of patients' torsos. What are the benefits of that approach?
X-rays used to monitor scoliosis measure only the sideways curve in the spine. We're developing quantitative ways to measure body shape in 3D: A smartphone or tablet with a special sensor completes the scan in under a minute and creates a 3D reconstruction to correlate with X-ray findings. My colleague Michael Gardner, MD, has used this technology to describe how body shape changes when someone has a fracture, and now we're applying it to scoliosis. This approach may help track bracing outcomes; help us monitor kids with mild scoliosis to determine whether they need treatment; and reduce radiation exposure for our patients.
About 1 in every 100 scoliosis patients need spinal fusion. How is your team working to improve this surgery?
A patient's No. 1 concern about scoliosis surgery is pain afterward. We have made great advances to reduce that. For the past year, we've been working with our anesthesiologists to put pain catheters around spine that deliver anesthesia to the site of the surgery over the next two days.
Anecdotally, this seems to reduce pain with fewer side effects. Anesthesiologist Chi-Ho Ban Tsui, MD, and I have received a grant to conduct a prospective randomized controlled trial testing whether this technique helps patients recover with recover with fewer opioids and get back to normal activities more quickly.
Image by Africa Studio
Infectious disease
Stanford ENT surgeon discusses how viruses cause a loss of sense of smell, and what you should do about it in the era of the coronavirus pandemic.
Infectious disease
From how to quarantine to how to monitor your oxygen levels, a Stanford physician offers tips on what to do if you have COVID-19.
Read the original here:
Stanford surgeon studies how to improve scoliosis treatment - Scope - Scope
- Muscular .Dystrophy -Successful-treatment by acupressure , Ayurveda, Yoga [Last Updated On: May 10th, 2011] [Originally Added On: May 10th, 2011]
- Muscular Dystrophy Treatment - Todd Harrison Improving Balance [Last Updated On: May 16th, 2011] [Originally Added On: May 16th, 2011]
- Oculopharyngeal Muscular Dystrophy (OPMD): Exploring Causes and Treatment [Last Updated On: May 20th, 2011] [Originally Added On: May 20th, 2011]
- Muscular Dystrophy Treatment - Todd Harrison holding body weight [Last Updated On: May 21st, 2011] [Originally Added On: May 21st, 2011]
- David G VECTTOR Muscular Dystrophy Treatment double arm strength month 6 [Last Updated On: May 22nd, 2011] [Originally Added On: May 22nd, 2011]
- David Gould Becker Muscular Dystrophy VECTTOR Treatment [Last Updated On: June 2nd, 2011] [Originally Added On: June 2nd, 2011]
- Muscular Dystrophy Halo [Last Updated On: June 3rd, 2011] [Originally Added On: June 3rd, 2011]
- Muscular Dystrophy VECTTOR Treatment Documentary - Todd's 6 Month Journey [Last Updated On: June 7th, 2011] [Originally Added On: June 7th, 2011]
- Muscular Dystrophy Treatment Results - David Gould - New Footage [Last Updated On: June 8th, 2011] [Originally Added On: June 8th, 2011]
- Muscular Dystrophy - Rewriting History with VECTTOR [Last Updated On: June 10th, 2011] [Originally Added On: June 10th, 2011]
- Muscular Dystrophy - David Gould 5 month VECTTOR treatment for BMD [Last Updated On: June 12th, 2011] [Originally Added On: June 12th, 2011]
- Duchenne's Muscular Dystrophy Stem Cell Treatment - Reelabs India [Last Updated On: June 14th, 2011] [Originally Added On: June 14th, 2011]
- Muscular Dystrophy VECTTOR Treatment - Todd Harrison/Luau Presentation [Last Updated On: June 16th, 2011] [Originally Added On: June 16th, 2011]
- Dr. William Rader - Muscular Dystrophy Breakthrough [Last Updated On: June 16th, 2011] [Originally Added On: June 16th, 2011]
- Muscular Dystrophy patient at Xcell-center - Nabeel Mohamed Abdulhusain, 46 years [Last Updated On: June 17th, 2011] [Originally Added On: June 17th, 2011]
- Charlie's Story: Duchenne Muscular Dystrophy Part 4 [Last Updated On: July 18th, 2011] [Originally Added On: July 18th, 2011]
- Muscular Dystrophy VECTTOR Treatment - David Gould/Luau Presentation [Last Updated On: July 19th, 2011] [Originally Added On: July 19th, 2011]
- Testimonial 4 of Muscular Dystrophy after Stem Cell Therapy [Last Updated On: August 5th, 2011] [Originally Added On: August 5th, 2011]
- Drug Combo Dynamic in Muscular Dystrophy [Last Updated On: August 9th, 2011] [Originally Added On: August 9th, 2011]
- Testimonial for Fetal Stem Cell Treatment of Duchenne Muscular Dystrophy [Last Updated On: August 25th, 2011] [Originally Added On: August 25th, 2011]
- Improvement seen in Duchenne Muscular Dystrophy after Stem Cell Therapy [Last Updated On: September 11th, 2011] [Originally Added On: September 11th, 2011]
- Muscular Dystrophy STS/VECTTOR treatment results [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- Muscular Dystrophy VECTTOR Treatment Documentary - Todd's One Year Journey [Last Updated On: October 2nd, 2011] [Originally Added On: October 2nd, 2011]
- Muscular Dystrophy Treatment Day 18 - Todd Harrison's Improvement [Last Updated On: October 2nd, 2011] [Originally Added On: October 2nd, 2011]
- Wang Yisheng - Muscular Dystrophy Adult Stem Cell Patient [Last Updated On: October 9th, 2011] [Originally Added On: October 9th, 2011]
- Becker Muscular Dystrophy Miracle TREATMENT [Last Updated On: October 11th, 2011] [Originally Added On: October 11th, 2011]
- Muscular dystrophy patient_Kleber_Brazil.wmv [Last Updated On: October 12th, 2011] [Originally Added On: October 12th, 2011]
- Testimonial 1 of Muscular Dystrophy after Stem Cell Therapy - Video [Last Updated On: October 18th, 2011] [Originally Added On: October 18th, 2011]
- Becker Muscular Dystrophy STS Treatment - Video [Last Updated On: October 18th, 2011] [Originally Added On: October 18th, 2011]
- Potential Stem Cell treatment of Duchenne Muscular Dystrophy - Video [Last Updated On: October 21st, 2011] [Originally Added On: October 21st, 2011]
- Muscular Dystrophy treated by Dr Rajesh Shah at Life Force - Video [Last Updated On: October 22nd, 2011] [Originally Added On: October 22nd, 2011]
- Defying Muscular Dystrophy - I Made It - Video [Last Updated On: October 23rd, 2011] [Originally Added On: October 23rd, 2011]
- Becker Muscular Dystrophy AMAZING treatment results - Video [Last Updated On: October 27th, 2011] [Originally Added On: October 27th, 2011]
- First targeted treatment success for Duchenne muscular dystrophy - Video [Last Updated On: November 6th, 2011] [Originally Added On: November 6th, 2011]
- 125 Days of VECTTOR Treatment Progress [Last Updated On: November 18th, 2011] [Originally Added On: November 18th, 2011]
- Becker Muscular Dystrophy WALKING ABILITY IMPROVED - Video [Last Updated On: November 25th, 2011] [Originally Added On: November 25th, 2011]
- PT Muscular Dystrophy Treatment Results - Video [Last Updated On: December 5th, 2011] [Originally Added On: December 5th, 2011]
- Duchenne Muscular Dystrophy Treated by Cellmedicine - Video [Last Updated On: January 8th, 2012] [Originally Added On: January 8th, 2012]
- muscular DYSTROPHY treatment IN HOMEOPATH.mp4 - Video [Last Updated On: January 28th, 2012] [Originally Added On: January 28th, 2012]
- Giulio's strategy is to cure dystrophy with stem cell treatment - Video [Last Updated On: January 31st, 2012] [Originally Added On: January 31st, 2012]
- Parent Project Muscular Dystrophy is a Featured Nonprofit Selected by Webkinz(TM) Foundation [Last Updated On: February 1st, 2012] [Originally Added On: February 1st, 2012]
- MDA Awards More Than $12 Million in Grants to Advance Neuromuscular Disease Research [Last Updated On: February 1st, 2012] [Originally Added On: February 1st, 2012]
- "For treatment we will have in the future" - Video [Last Updated On: February 2nd, 2012] [Originally Added On: February 2nd, 2012]
- Renowned Pediatric Cardiology Physician-Scientist Linda Cripe Joins Nationwide Children's Hospital [Last Updated On: February 3rd, 2012] [Originally Added On: February 3rd, 2012]
- JumpStart Invests $250,000 in Milo Biotechnology [Last Updated On: February 14th, 2012] [Originally Added On: February 14th, 2012]
- When nerve meets muscle, biglycan seals the deal [Last Updated On: February 14th, 2012] [Originally Added On: February 14th, 2012]
- Medical clinics offer help for Big Island children [Last Updated On: February 16th, 2012] [Originally Added On: February 16th, 2012]
- Dateline Long Beach: The Aquatic Center brings swim therapy to disabled [Last Updated On: February 19th, 2012] [Originally Added On: February 19th, 2012]
- Parent Project Muscular Dystrophy Awards $500,000 to Tivorsan Pharmaceuticals [Last Updated On: February 21st, 2012] [Originally Added On: February 21st, 2012]
- Cure Duchenne Announces Three New Funded Research Projects to Help Develop Treatments and Find a Cure for Duchenne ... [Last Updated On: February 21st, 2012] [Originally Added On: February 21st, 2012]
- Ligand Licenses DARA Program to Retrophin [Last Updated On: February 21st, 2012] [Originally Added On: February 21st, 2012]
- AVI BioPharma Regains NASDAQ Compliance [Last Updated On: February 23rd, 2012] [Originally Added On: February 23rd, 2012]
- Scientists create potent molecules aimed at treating muscular dystrophy [Last Updated On: February 23rd, 2012] [Originally Added On: February 23rd, 2012]
- AVI BioPharma Announces Fourth Quarter and Full Year 2011 Financial Results and Corporate Update Conference Call [Last Updated On: February 23rd, 2012] [Originally Added On: February 23rd, 2012]
- Pembroke's Christine McSherry is an 'Inspirational Woman' [Last Updated On: February 25th, 2012] [Originally Added On: February 25th, 2012]
- The Rare Clinical Diseases Research Network [Last Updated On: February 25th, 2012] [Originally Added On: February 25th, 2012]
- A Solution for Duchenne Muscular Dystrophy? - Research Summary [Last Updated On: February 28th, 2012] [Originally Added On: February 28th, 2012]
- A Solution for Duchenne Muscular Dystrophy? -- In Depth Doctor's Interview [Last Updated On: February 28th, 2012] [Originally Added On: February 28th, 2012]
- Antisense oligonucleotides make sense in myotonic dystrophy [Last Updated On: February 28th, 2012] [Originally Added On: February 28th, 2012]
- A life of dependence [Last Updated On: February 29th, 2012] [Originally Added On: February 29th, 2012]
- Nationwide Children's Hospital neuromuscular disorder podcasts now available on iTunes [Last Updated On: March 2nd, 2012] [Originally Added On: March 2nd, 2012]
- Next-generation DNA sequencing to improve diagnosis for muscular dystrophy [Last Updated On: March 6th, 2012] [Originally Added On: March 6th, 2012]
- The Dire Limits of Health Care [Last Updated On: March 7th, 2012] [Originally Added On: March 7th, 2012]
- AVI BioPharma Announces Late-Breaker Oral Presentation of Phase IIb DMD Study at 2012 AAN Annual Meeting in April [Last Updated On: March 12th, 2012] [Originally Added On: March 12th, 2012]
- Cataracts affect millions of people around the globe, and for many of us they will be a normal part of our aging ... [Last Updated On: March 14th, 2012] [Originally Added On: March 14th, 2012]
- Your Health: Duchenne's Muscular Dystrophy [Last Updated On: March 16th, 2012] [Originally Added On: March 16th, 2012]
- Newborn Screening for Duchenne Muscular Dystrophy Shows Promise as an International Model [Last Updated On: March 20th, 2012] [Originally Added On: March 20th, 2012]
- Newborn screening for DMD shows promise as an international model [Last Updated On: March 20th, 2012] [Originally Added On: March 20th, 2012]
- Rhenovia launches drug discovery for Huntington's disease [Last Updated On: March 20th, 2012] [Originally Added On: March 20th, 2012]
- Halo Therapeutics Reports Favorable Independent Review of Lead Drug Candidate HT-100 [Last Updated On: March 21st, 2012] [Originally Added On: March 21st, 2012]
- Invasive treatment strategy may increase survival for patients with certain neuromuscular disorder [Last Updated On: March 28th, 2012] [Originally Added On: March 28th, 2012]
- Parent Project Muscular Dystrophy Endorses FAST Act Legislation to Expedite FDA Review of Life-Saving Therapies [Last Updated On: March 29th, 2012] [Originally Added On: March 29th, 2012]
- AVI BioPharma Announces Conference Call and Webcast on Monday, April 2, 2012, to Discuss Top-Line Data Results From ... [Last Updated On: March 31st, 2012] [Originally Added On: March 31st, 2012]
- Drug for rare disease may lift AVI BioPharma shares: Barron's [Last Updated On: April 2nd, 2012] [Originally Added On: April 2nd, 2012]
- AVI BioPharma Announces Eteplirsen Meets Primary Endpoint, Demonstrating a Significant Increase in Dystrophin at 24 ... [Last Updated On: April 2nd, 2012] [Originally Added On: April 2nd, 2012]
- U.S. Stock Futures Little Changed Before Factory Report [Last Updated On: April 2nd, 2012] [Originally Added On: April 2nd, 2012]
- Leading experts on congenital muscular dystrophy convene at University of Nevada, Reno [Last Updated On: April 20th, 2012] [Originally Added On: April 20th, 2012]
- Nature Publishes Work Utilizing N-Gene's Core Technology to Advance the Treatment of Duchenne Muscular Dystrophy [Last Updated On: April 20th, 2012] [Originally Added On: April 20th, 2012]
- Getting the boots filled [Last Updated On: April 29th, 2012] [Originally Added On: April 29th, 2012]
- Local business, civic leaders 'arrested' for MDA fundraiser [Last Updated On: May 3rd, 2012] [Originally Added On: May 3rd, 2012]