TiGenix gets European patent relating to adipose-derived stem cell composition

Published 23 January 2015

TiGenix, an advanced biopharmaceutical company focused on developing and commercialising novel therapeutics from its proprietary platform of allogeneic expanded adipose-derived stem cells in inflammatory and autoimmune diseases, announced that the European Patent Office (EPO) has issued European Patent EP2292736 relating to an adipose-derived stem cell composition.

The patent is entitled " Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue ". The claims of the granted patent cover both a specified population of expanded adipose-derived multipotent cells and their therapeutic uses, as well as pharmaceutical compositions of such cells.

TiGenix is developing injectable products from its proprietary platform of allogeneic expanded adipose-derived stem cells (eASCs) for inflammatory and autoimmune diseases. Cx601 is a solution of allogeneic eASCs for local injection currently in Phase III of clinical development for the treatment of complex perianal fistulas in patients with Crohn's disease.

Clinical results from the on-going European Phase III trial are expected in the third quarter of 2015, and, if positive, may allow the company to file for Marketing Authorisation in Europe. Cx611 is an intravenously-administered product of allogeneic eASCs, which TiGenix is currently developing for patients with early rheumatoid arthritis and for patients with severe sepsis.

"This European patent further strengthens our intellectual property position in the field of expanded adipose-derived stem cell compositions and their therapeutic uses", said Wilfried Dalemans, Chief Technical Officer of TiGenix. "The grant of this patent advances our leading position in bringing adipose-derived stem cell therapeutics to patients."

The issuance of this patent reinforces TiGenix's intellectual property portfolio of 24 patent families which now includes 14 granted patents related specifically to its eASC platform.

The pending and granted patents in TiGenix's intellectual property portfolio include patent families that are directed to its eASC platform; and more specifically, to eASC compositions and therapeutic applications as well as to cell therapy delivery mechanisms and other eASC technology improvements.

Source: Company Press Release

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TiGenix gets European patent relating to adipose-derived stem cell composition