Using synthetic biology to make new antibiotics

Using synthetic biology to make new antibiotics

Research at Victoria University of Wellington could lead to a new generation of antibiotics, helping tackle the global issue of superbugs that are resistant to modern medicine.

Led by Mark Calcott, who has just completed his PhD study, under the supervision of Dr David Ackerley, an associate professor in the School of Biological Science, the research is delivering new knowledge about how synthetic biology might be used to counter bacteria that have become resistant to existing antibiotics.

The recently published study defines new ways that microbes, which are used to make some commonly used types of antibiotics, can be reengineered to produce modified forms of the original molecules.

Part of the problem is that people have historically been careless when using antibiotics, which has, one-by-one, allowed bacteria to build resistance, thrive and multiply. Were smarter now, but at a time when were running out of options, says Dr Ackerley.

There is a serious and immediate need for new antibioticseither we have to develop the next generation or find clever and affordable ways of modifying the ones we currently have, he says.

The basis of our research is the idea that the microbial machinery (enzymes) that makes a particular antibiotic can be rearranged, to make a different antibiotic that resistant bacteria wont recognise. The new antibiotics will still fight infection, and if we can use them in a more targeted way, bacteria wont become resistant so easily.

He says the ultimate goal of the study is to be able to produce high yields of new and affordable antibiotics that superbugs dont recognise and are not resistant to.

Results have been published by the American Society for Microbiology journal Applied and Environmental Microbiology, viewable online here: http://bit.ly/1jpXM9U

The research is a core output of a grant Dr Ackerley has received from the Marsden Fund for a project called Cracking the non-ribosomal code. Dr Ackerley is collaborating with Professor Iain Lamont from the Department of Biochemistry at Otago University.

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Using synthetic biology to make new antibiotics