Vascular Biology Chicago Medicine

Cho, Jaehyung Gus

Ph.D., University of Wisconsin-MadisonAssociate Professorthromres@uic.edu

Research InterestsCardiovascular Biology, Immunology, Vascular Biology

Research Description

Mechanisms regulating platelet-neutrophil-endothelial cell interactions during thrombosis and inflammation; intravital microscopy in live animals.

PhD, University of California, San DiegoProfessor of Physiology and Biophysics and MedicinePrima@UIC.edu 312-996-6430

Research InterestsSignal Transduction and Cell Signaling, Gene Regulation, Vascular Biology

Research Description

The cytoskeleton in signal transduction; Molecular motors in the nucleus

M.D., Ph.D., University of Sydney, AustraliaProfessor of Pharmacologyxdu@uic.edu 312-355-0237

Research InterestsVascular Biology, Signal Transduction and Cell Signaling,

Research Description

Thrombosis,hemostasis, and vascular biology; molecular mechanisms and molecular pharmacology of platelet and endothelial cell functions.

MD, PhD, Kyushu University, Fukuoka, JapanAssociate Professor of Medicine, Section of Cardiology, and Pharmacologytfukai@uic.edu 312-996-6730

Research InterestsGene Regulation, Molecular Biology, Vascular Biology

Research Description

To determine the role of oxidative stress and copper transport system in cardiovascular disease.

MD, PhD/China Medical UniversityAssociate Professor, Pharmacology and Anesthesiologygchu@uic.edu (312) 996-4692

Research InterestsLung Biology, Immunology, Vascular Biology

Research Description

Identify molecular regulatory mechanisms of innate immunity and inflammation, vascular endothelial barrier function, and acute lung injury/ARDS

PhD, University of TorontoAssociate Professor of Pharmacologysclam@uic.edu 312-413-5928

Research InterestsBiochemistry, Vascular Biology,

Research Description

Platelet adhesive functions in hemostasis and thrombosis; structure- function relationship of integrin alpha IIb?3.

Ph.D., University of ChicagoProfessor of PharmacologyGCL@uic.edu 312-996-4929

Research InterestsVascular Biology, Signal Transduction and Cell Signaling, Molecular Pharmacology

Research Description

Fundamental mechanisms and signal transduction processes involved in platelet activation and inhibition.

Ph.D., University of Toronto, CanadaDistinguished Professor and Head, Department of Pharmacologyabmalik@uic.edu312-996-7635

Research InterestsCell and Membrane Biology, Host-Pathogen Biology, Lung Biology, Molecular Pharmacology, Stem Cell Biology, Vascular Biology

Research DescriptionGene regulation in endothelial cells; expression of adhesion molecules and their transcriptional regulation; regulation of endothelial transport;assembly of adherens junctions; function of caveolin-1 inendothelial cells.

Ph.D., Delhi University, IndiaAssistant Professor of Pharmacologydmehta@uic.edu 312-355-0236

Research InterestsVascular Biology, Signal Transduction and Cell Signaling, Cell and Membrane Biology

Research Description

Rho regulation of actin polymerization.

Ph.D., University of Illinois at ChicagoAssociate Professor of Pharmacology and Anesthesiologyrminsh@uic.edu 312-996-1655

Research InterestsVascular Biology, Signal Transduction and Cell Signaling, Bio-imaging

Research Description

Investigates signaling mechanisms regulating paracellular and transcellular permeability of the endothelium to macromolecules and therapeuticagents. Confocal microscopy, physiological, molecular, cellular, and biochemical approaches are used to study trafficking of caveolae,organization and remodeling of the cytoskeleton and cell-celljunctions, protein and fluid permeability, and signaling modules thatregulate endothelial cell function. Current projects focus on 1) the signaling molecules that regulate caveolae-mediated endocytosis and transcytosis, 2) delivery of therapeutic agents across the vascular barrier, and 3) the role of caveolae in inflammation-induced increasein permeability.

PhDAssistant Professorpcwkyh17@uic.edu

Research InterestsDevelopment, Stem Cell Biology, Vascular Biology

Research Description

To study the biology of vascular endothelial cells with mouse genetics and embryonic stem (ES) cells.

MDAssociate Professorjalees@uic.edu

Research InterestsStem Cell Biology, Vascular Biology, Metabolism/Biochemistry

Research Description

My laboratory studies the biology of regenerative stem and progenitor cells in the cardiovascular system.

Ph.D., University of California, San DiegoProfessor of Pharmacologyrskidgel@uic.edu 312-996-9179

Research InterestsMolecular Pharmacology, Vascular Biology, Signal Transduction and Cell Signaling

Research Description

Role of peptidases in the regulation of G protein-coupled receptor signaling and the function of nitric oxide synthases in vascular disease.

Ph.D., University of MadrasAssociate Professor of Pharmacologytiruc@uic.edu 312-355-0249

Research InterestsVascular Biology, Cell and Membrane Biology,

Research Description

Our primary research interest is to study the molecular mechanism that regulates vascular inflammation. Pro- inflammatory mediator thrombininduces vascular inflammation by cleaving the endothelial cell surface protease activated receptor-1 (PAR-1). PAR-1 activation causes vascular leakage and neutrophil adhesion-mediated vascular injury. Ca2+signaling plays an important role in the mechanism of thrombin-induced vascular injury. Currently, we are investigating how thrombin increases intracellular Ca2+ by opening plasma membrane transient receptor potential channels expressed in endothelial cells. In addition, we are also investigating the role of Ca2+ signaling in the mechanism of nuclear factor ?B (NF-?B) activation- dependent expression of inflammatory genes in endothelial cells.

PhD, Kyushu University, Fukuoka, JapanAssociate Professor of Pharmacologymfukai@uic.edu 312-996-7665

Research InterestsCell Biology and Signaling, Signal Transduction and Cell Signaling, Vascular Biology

Research Description

To determine the role of reactive oxygen species in angiogenesis and cardiovascular diseases using cell culture, live cell imaging, cell fractionation, molecular and cell biological analysis as well as in vivomodels with knockout and transgenic mice.

M.D., Ph.D., Institute of Pathophysiology, MoscowAssociate Professor of Pharmacologytvy@uic.edu 312-996-9823

Research InterestsSignal Transduction and Cell Signaling, Vascular Biology, Molecular Pharmacology

Research Description

G-protein regulatory mechanisms and control of cellular proliferation and cytoskeleton.

PhD, North Eastern Hill University, IndiaAssistant Professor of Pharmacologykkwary@uic.edu 312-413-9582

Research InterestsSignal Transduction and Cell Signaling, Vascular Biology, Lung Biology

Research Description

Biology of endothelial cells; cell- cell and cell-matrix interactions in endothelial cells; integrin, beta- catenin, VE-cadherin and Wnt mediated signaling in endothelial cells; adult stem cells; wound healing;angiogenesis and tumor progression.

MD, PhDProfessorjxyuan@uic.edu

Research InterestsVascular Biology, Signal Transduction and Cell Signaling, Cell and Membrane Biology

Research Description

Pathogenic mechanisms of pulmonary arterial hypertension; ion channel electrophysiology; calcium signaling; hypoxic pulmonary vasoconstriction; smooth muscle cell migration, proliferation and apoptosis; stem cell proliferation and differentiation.

PhDProfessor of Pharmacologyyyzhao@uic.edu312-355-0238

Research Interests

Lung Biology, Vascular Biology, Signal Transduction and Cell Signaling

Research Description

Mechanisms of endothelial regeneration and resolution of inflammatory injury in sepsis and acute respiratory distress syndrome. Molecular basis of pulmonary vascular remodeling and pulmonary hypertension. Focus on endothelial cell biology but also study the crosstalk between endothelial cells and other cells such as macrophages, smooth muscle cells, and stem/progenitor cells.

Read more here:

Vascular Biology Chicago Medicine