A new global study aims to establish whether a new class of drug can reduce the risk of heart attacks or strokes
3,000 people in the UK who have suffered a heart attack or stroke or have peripheral arterial disease are being recruited for a world-wide study which will investigate medication that could lower the risk of patients having a second cardiovascular event.
The new study called FOURIER (sponsored by Amgen Inc. and supported by the Imperial College Clinical Trials Unit) has been launched in the UK as part of a global programme (also taking place across Europe, US, Canada, Australia, Asia and Latin America) to provide more evidence to inform and guide future strategies in the secondary prevention of cardiovascular disease
The study will investigate whether taking a new type of treatment, which studies so far suggest can reduce LDL cholesterol by about 50%, on top of a statin will reduce the risk of major cardiovascular events compared to just taking statin therapy.
22,500 people who have had an ischaemic stroke, a heart attack or who have peripheral arterial disease are being recruited world-wide for the trial which is expected to last 5 years. People taking part in the study will receive an experimental cholesterol lowering study drug in combination with optimal statin therapy OR optimal statin therapy alone.
Over 1800 people have taken part in earlier phase studies with this agent to date and studies where it was given on top of a statin indicate it can reduce LDL cholesterol by over 50% compared to statin therapy alone. The new medication currently being researched is not yet licensed for use.
More people die from cardiovascular disease (CVD) each year than any other cause.[ii] In the UK the main cause of death was CVD, accounting for almost 180,000 deaths in 2010 - around 1 in 3 of all deaths.[iii] Almost half (48%) of all CVD deaths was due to coronary heart disease (CHD) and over a quarter (28%) are from stroke.
If you have already had a heart attack or stroke or have peripheral arterial disease this puts you at greater risk of having a second cardiovascular event.
However, the risk of recurrence or death can be substantially lowered with a combination of drugs - statins to lower cholesterol, drugs to lower blood pressure, and aspirin.
High cholesterol is a major contributor to cardiovascular disease. Every 1 mmol/L reduction in LDL cholesterol (the bad cholesterol) reduces the annual risk of a heart attack or stroke by 20%.
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